Effects of electroacupuncture at ST36 and BL20 on the diabetic rat testis

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dc.authoridErsoy, Onur/0000-0001-9829-7903
dc.authoridBozer, Cuneyt/0000-0002-2001-6056
dc.authorwosidErsoy, Onur/AAZ-5121-2020
dc.authorwosidYılmaz, Ali/KLZ-9798-2024
dc.authorwosiddemirtaş, selim/JED-6784-2023
dc.contributor.authorKizilay, Gulnur
dc.contributor.authorErsoy, Onur
dc.contributor.authorBozer, Cuneyt
dc.contributor.authorDemirtas, Selim
dc.contributor.authorCikmaz, Selman
dc.contributor.authorYilmaz, Ali
dc.date.accessioned2024-06-12T10:50:31Z
dc.date.available2024-06-12T10:50:31Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: We aimed to evaluate the effects of electroacupuncture (EA) at ST36 and BL20 on the testicular tissues in a rat model of diabetes and to explore the mechanisms of action. Methods: A total of 34 male Sprague-Dawley rats were allocated to a control group (n = 10), diabetes (D) group (n = 12) or diabetes + acupuncture (DA) group (n = 12). To model diabetes, rats in groups D and DA received an intraperitoneal injection of a single dose of 35 mg/kg streptozotocin (STZ) dissolved in citrate buffer (pH = 4.5; 0.1 M) after 2 weeks of high-fat diet administration. Under xylazine/ketamine anesthesia, stainless steel needles (30 mm x 0.25 mm) were inserted bilaterally at ST36 and BL20. The needles were connected to an EA device via cables, and EA was applied for 30 min (15 Hz frequency and 0.2-1 mA intensity) twice a week for 5 weeks. Results: The effects of EA at ST36 and BL20 on blood glucose levels and body weight, biochemical parameters, histopathological, morphometric and immunohistochemical findings, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) analysis were evaluated. A significant decrease was detected in DA versus D groups in blood glucose levels, basement membrane thickness and apoptotic cell/tubule indices. In addition, there was a significant increase in the Johnsen scores, seminiferous tubule diameters, serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone, proliferation indices, and sex hormone-binding globulin (SHBG) and insulin-like peptide 3 (INSL3) immunoreactivities. Conclusion: EA had multiple positive effects on blood glucose homeostasis and testicular structure/function in this rat model of diabetes. EA may be effective at preventing or eliminating histopathological damage in the diabetic testis.en_US
dc.description.sponsorshipTrakya University Scientific Research Project Unit [TUBAP-2018/220]en_US
dc.description.sponsorshipThe authors disclosed receipt of the following financial support for the research, authorship and/or publication of this article: This study was supported by the Trakya University Scientific Research Project Unit (TUBAP-2018/220).en_US
dc.identifier.doi10.1177/09645284221146196
dc.identifier.endpage306en_US
dc.identifier.issn0964-5284
dc.identifier.issn1759-9873
dc.identifier.issue5en_US
dc.identifier.pmid36655632en_US
dc.identifier.scopus2-s2.0-85147346954en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage297en_US
dc.identifier.urihttps://doi.org/10.1177/09645284221146196
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18030
dc.identifier.volume41en_US
dc.identifier.wosWOS:000922390500001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofAcupuncture In Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcupunctureen_US
dc.subjectApoptosisen_US
dc.subjectDiabetic Testesen_US
dc.subjectInsulin-Like Peptide 3en_US
dc.subjectSex Hormone-Binding Globulinen_US
dc.subjectTesticular Apoptosisen_US
dc.subjectInsulin Sensitivityen_US
dc.subjectAcupunctureen_US
dc.subjectProteinen_US
dc.subjectInnervationen_US
dc.subjectDysfunctionen_US
dc.subjectActivationen_US
dc.subjectCellsen_US
dc.subjectModelen_US
dc.subjectEpididymisen_US
dc.titleEffects of electroacupuncture at ST36 and BL20 on the diabetic rat testisen_US
dc.typeArticleen_US

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