Avoiding Liver Injury with Papaverine and Ascorbic Acid Due to Infrarenal Cross-Clamping: an Experimental Study

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dc.authoridYuksel, Volkan/0000-0001-9518-2588
dc.authoridHuseyin, Serhat/0000-0003-4118-040X
dc.authoridGUCLU, Orkut/0000-0001-6460-3175
dc.authorwosidCan, Nuray/D-3452-2016
dc.authorwosidGUCLU, Orkut/H-9993-2014
dc.contributor.authorHuseyin, Serhat
dc.contributor.authorGuclu, Orkut
dc.contributor.authorYuksel, Volkan
dc.contributor.authorErkul, Gulen Sezer Alptekin
dc.contributor.authorCan, Nuray
dc.contributor.authorTuran, Fatma Nesrin
dc.contributor.authorCanbaz, Suat
dc.date.accessioned2024-06-12T11:13:36Z
dc.date.available2024-06-12T11:13:36Z
dc.date.issued2017
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: Ischemia-reperfusion injury after acute ischemia treatment is a serious condition with high mortality and morbidity. Ischemia-reperfusion injury may result in organ failure particularly in kidney, lung, liver, and heart. In our study, we investigated the effects of papaverine and vitamin C on ischemia-reperfusion injury developed in the rat liver after occlusion-reperfusion of rat aorta. Methods: 32 Sprague-Dawley female rats were randomized into four groups (n=8). Ischemia was induced with infrarenal aortic cross-clamping for 60 minutes; then the clamp was removed and reperfusion was allowed for 120 minutes. While the control group and the ischemia-reperfusion group did not receive any supplementary agent, two other groups received vitamin C and papaverine hydrochloride (papaverine HCL). Liver tissues were evaluated under the light microscope. Histopathological examination was assessed by Suzuki's criteria and results were compared between groups. Results: In ischemia-reperfusion group, severe congestion, severe cytoplasmic vacuolization, and parenchymal necrosis over 60% (score 4) were observed. In vitamin C group, mild congestion, mild cytoplasmic vacuolization and parenchymal necrosis below 30% (score 2) were found. In papaverine group, moderate congestion, moderate cytoplasmic vacuolization and parenchymal necrosis below 60% (score 3) were observed. Conclusion: An ischemia of 60 minutes induced on lower extremities causes damaging effects on hepatic tissue. Vitamin C and papaverine are helpful in reducing liver injury after acute ischemia reperfusion and may partially avoid related negative conditions.en_US
dc.identifier.doi10.21470/1678-9741-2016-0081
dc.identifier.endpage201en_US
dc.identifier.issn0102-7638
dc.identifier.issn1678-9741
dc.identifier.issue3en_US
dc.identifier.pmid28832798en_US
dc.identifier.scopus2-s2.0-85027715399en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage197en_US
dc.identifier.urihttps://doi.org/10.21470/1678-9741-2016-0081
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23599
dc.identifier.volume32en_US
dc.identifier.wosWOS:000418357200010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Brasil Cirurgia Cardiovascen_US
dc.relation.ispartofBrazilian Journal Of Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectReperfusion Injuryen_US
dc.subjectLiver Diseasesen_US
dc.subjectPapaverineen_US
dc.subjectAscorbic Aciden_US
dc.subjectRatsen_US
dc.subjectModels, Animalen_US
dc.subjectIschemia-Reperfusion Injuryen_US
dc.subjectLung Injuryen_US
dc.subjectRaten_US
dc.subjectPathophysiologyen_US
dc.subjectMelatoninen_US
dc.titleAvoiding Liver Injury with Papaverine and Ascorbic Acid Due to Infrarenal Cross-Clamping: an Experimental Studyen_US
dc.typeArticleen_US

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