Investigation of Risk Factors Related to the Development of Hepatic Dysfunction in Patients with a Low and Moderate Cardiac Risk During Open-Heart Surgeries

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dc.authoridsagiroglu, gonul/0000-0002-1189-4973
dc.authorwosidBaysal, Ayse/AAR-8769-2021
dc.authorwosidSagiroglu, Gonul/ABH-1345-2021
dc.authorwosiddoğukan, mevlüt/HJY-5235-2023
dc.contributor.authorBaysal, Ayse
dc.contributor.authorSagiroglu, Gonul
dc.contributor.authorDogukan, Mevlut
dc.contributor.authorOzkaynak, Ismail
dc.date.accessioned2024-06-12T11:03:34Z
dc.date.available2024-06-12T11:03:34Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: To determine the possible risk factors associated with hepatic dysfunction during open-heart surgeries. Methods: After excluding 71 patients, 307 patients with possible low and moderate cardiac risk who underwent either coronary artery bypass graft surgery (CABG) (n=176) or valve repair surgery (mitral valve, mitral and aortic valves and/or tricuspid valve) (n=131) were investigated prospectively during a 6-month period. Hyperbilirubinemia is defined as an occurrence of a plasma total bilirubin concentration >34 mu mol/L (2 mg/dL) in any measurement during the postoperative period; the patients were divided into groups with or without postoperative hyperbilirubinemia. The collected parameters were: alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), total bilirubin (TBil), gamma-glutamyl transpeptidase (GGT) and albumin. The parameters were collected preoperatively and postoperatively on days 1, 3 and 7. Preoperative, intraoperative, and postoperative risk factors were investigated. Logistic regression analysis was performed to identify the risk factors for postoperative hyperbilirubinemia. Results: Postoperative hyperbilirubinemia was observed in 7 of 176 patients (4%) who underwent CABG, and in 11 of 131 patients (8.4%) who underwent valve replacement surgeries. Independent risk factors for early postoperative hyperbilirubinemia were found as: ejection fraction (EF), aortic cross-clamp (ACC) time, intensive care unit stay and extubation time (P<0.001). In comparison to CABG procedures, postoperative hyperbilirubinemia was observed more frequently in patients undergoing valve surgeries (P=0.027). Conclusion: Low EF and prolonged ACC time are significant independentrisk factors for early postoperative hyperbilirubinemia during open-heart surgeries with cardiopulmonary bypass. Valve surgeries show a higher incidence of hyperbilirubinemia in comparison to CABG.en_US
dc.identifier.doi10.21470/1678-9741-2019-0427
dc.identifier.endpage228en_US
dc.identifier.issn0102-7638
dc.identifier.issn1678-9741
dc.identifier.issue2en_US
dc.identifier.pmid34048203en_US
dc.identifier.scopus2-s2.0-85104552729en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage219en_US
dc.identifier.urihttps://doi.org/10.21470/1678-9741-2019-0427
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21689
dc.identifier.volume36en_US
dc.identifier.wosWOS:000639634600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Brasil Cirurgia Cardiovascen_US
dc.relation.ispartofBrazilian Journal Of Cardiovascular Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHyperbilirubinemiaen_US
dc.subjectBilirubinen_US
dc.subjectAortic Valveen_US
dc.subjectCardiopulmonary Bypassen_US
dc.subjectPotoperative Complicationsen_US
dc.subjectStroke Volumeen_US
dc.subjectRisk Factorsen_US
dc.titleInvestigation of Risk Factors Related to the Development of Hepatic Dysfunction in Patients with a Low and Moderate Cardiac Risk During Open-Heart Surgeriesen_US
dc.typeArticleen_US

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