Effect of obesity on TAFI in postmenopausal period

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dc.authoridTaşkıran, Bengür/0000-0003-4842-450X
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.authorwosidTaşkıran, Bengür/AAA-3574-2020
dc.contributor.authorTaskiran, Bengur
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorDemir, Ahmet M.
dc.contributor.authorOkman, Tulay K.
dc.contributor.authorArikan, Ender
dc.contributor.authorTurgut, Burhan
dc.contributor.authorTugrul, Ayse A.
dc.date.accessioned2024-06-12T10:54:55Z
dc.date.available2024-06-12T10:54:55Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim: The aim of the study was to evaluate how obesity effects the coagulation and fibrinolytic system in the postmenopausal period. Method: Forty-eight obese (body mass index (BMI) >= 30 kg/m(2)) and 38 nonobese (BMI < 30 kg/m(2)) postmenopausal women were enrolled in the study. Fat mass and insulin resistance were calculated. Plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA), D-dimer, thrombomodulin, and thrombin activatable fibrinolysis inhibitor (TAFI) antigen were determined by ELISA method. TAFI activity was measured using the chromogenic assay. Results: Obese subjects had higher PAI-1 (73.5 +/- 35.7 ng/mL vs. 57.1 +/- 34.2 ng/mL, p < 0.05) levels but lower tPA/PAI-1 ratio (0.59 +/- 0.50 vs. 38 +/- 0.21, p < 0.05) than their nonobese counterparts. Obesity was not statistically significant for other haemostatic variables. BMI and fat mass were positively correlated with PAI-1 (r = 0.312, p = 0.003; r = 0.381, p = 0.005, respectively) and negatively correlated with tPA/PAI-1 ratio (r = -0.273, p = 0.01; r = -0.545, p = 0.01, respectively). HOMA scores were also positively correlated with PAI-1 levels (r = 0.236, p = 0.04). Conclusion: We found that tendency to hypercoagulability in the postmenopausal women was due to increased PAI-1 rather than TAFI levels, which may contribute to adverse cardiovascular outcomes in this cohort. Further studies should be undertaken to evaluate effects of weight loss on the coagulation and fibrinolytic system. (C) 2010 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipTrakya Universityen_US
dc.description.sponsorshipThe study was granted by Trakya University Scientific Research Projects Fund. The study has been presented as poster at 22th Congress of the International Society on Thrombosis and Haemostasis under the title Is there any effect of obesity on thrombin activatable fibrinolysis inhibitor levels in postmenopausal women? (Journal of Thrombosis and Haemostasis 2009; Volume 7, Suppl. 2: Abstract PP-TH221).en_US
dc.identifier.doi10.1016/j.orcp.2010.05.001
dc.identifier.endpageE276en_US
dc.identifier.issn1871-403X
dc.identifier.issn1878-0318
dc.identifier.issue4en_US
dc.identifier.pmid24345692en_US
dc.identifier.scopus2-s2.0-84865754135en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpageE271en_US
dc.identifier.urihttps://doi.org/10.1016/j.orcp.2010.05.001
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19220
dc.identifier.volume4en_US
dc.identifier.wosWOS:000208407800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofObesity Research & Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBody Mass Indexen_US
dc.subjectMenopauseen_US
dc.subjectInsulin Resistanceen_US
dc.subjectThrombosisen_US
dc.subjectTAFIen_US
dc.titleEffect of obesity on TAFI in postmenopausal perioden_US
dc.typeArticleen_US

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