Breast cancer, ovarian gonadoblastoma and cervical cancer in a patient with Peutz-Jeghers Syndrome

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dc.contributor.authorKilic-Okman, Tulay
dc.contributor.authorYardim, Turgut
dc.contributor.authorGucer, Fatih
dc.contributor.authorAltaner, Semsi
dc.contributor.authorYuce, M. Ali
dc.date.accessioned2024-06-12T11:12:19Z
dc.date.available2024-06-12T11:12:19Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder characterized by gastrointestinal hamartomatous polyps and mucocutaneous pigmentation. Patients with PJS have increased risk for gastrointestinal, breast, and female genital tract cancers. Case Multiple genital tract cancers in a 34-year-old woman with PJS are described. The patient, who was admitted to our department with severe vaginal bleeding, was performed right salpingo-oophorectomy because of pure gonadoblastoma in 1996. In 2003, concomitant to cervical carcinoma, breast cancer was diagnosed. Patient underwent left modified radical mastectomy due to the invasive papillary carcinoma. The patient received six cycles combination chemotherapy and radiation therapy because of stage IIIB cervical cancer. Conclusion(s) This is the first case report presenting PJS associated with multiple genital tract tumors including ovarian gonadoblastoma in literature. The clinical significance of these tumors in PJS patients has been reviewed.en_US
dc.identifier.doi10.1007/s00404-007-0535-x
dc.identifier.endpage77en_US
dc.identifier.issn0932-0067
dc.identifier.issn1432-0711
dc.identifier.issue1en_US
dc.identifier.pmid18193442en_US
dc.identifier.scopus2-s2.0-44449174552en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage75en_US
dc.identifier.urihttps://doi.org/10.1007/s00404-007-0535-x
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23122
dc.identifier.volume278en_US
dc.identifier.wosWOS:000256263300014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofArchives Of Gynecology And Obstetricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPeutz-Jeghers Syndromeen_US
dc.subjectGonadoblastomaen_US
dc.subjectBreasten_US
dc.subjectCervixen_US
dc.subjectCanceren_US
dc.subjectSex Cord Tumoren_US
dc.subjectAnnular Tubulesen_US
dc.titleBreast cancer, ovarian gonadoblastoma and cervical cancer in a patient with Peutz-Jeghers Syndromeen_US
dc.typeArticleen_US

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