The antioxidant effects of taurine, melatonin and N-acetylcysteine in cadmium-induced lung injury

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dc.authorwosidnikkhah, elham/M-6142-2017
dc.authorwosidAydogdu, Nurettin/ABH-9224-2020
dc.contributor.authorAydogdu, Nurettin
dc.contributor.authorErbas, Hakan
dc.contributor.authorKaymak, Kadir
dc.date.accessioned2024-06-12T10:50:21Z
dc.date.available2024-06-12T10:50:21Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: The potential protective and therapeutic effects of taurine, melatonin and N-acetylcysteine (NAC), which are recognized as antioxidant agents, in cadmium chloride (CdCl2)-induced lung injury were compared. Study Design: Ninety male Sprague-Dawley rats were divided into 9 groups. During the 3 months treatment period, group 1 received drinking water, group 2 200 ppm CdCl2, group 3 200 ppm CdCl2 and 1 % taurine, to, group 4, 200 ppm CdC12 and 0.02% melatonin, and group 5 received 200 ppm CdCl2 and 0.5% NAC all added into drinking water in each group. After, groups 6, 7, 8 and 9 received 200 ppm CdC12 in their drinking water for 3 months, group 6 was given drinking water, group 7, 4% taurine, group 8, 0.08% melatonin and group 9, 2% NAC, each for 7 days. Results: Melatonin and NAC which were given for protective purposes, increased the decreased glutathione levels. The 3 substances that were administered for both protective and therapeutic purposes, decreased the increased malondialclehyde levels, one of the end products of lipid peroxiclation. Conclusion: Taurine, melatonin and NAC play protective and therapeutic roles in CdC12 induced lung injury.en_US
dc.identifier.endpage48en_US
dc.identifier.issn1301-3149
dc.identifier.issue1en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/17973
dc.identifier.volume24en_US
dc.identifier.wosWOS:000257598600009en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherEkin Tibbi Yayincilik Ltd Sti-Ekin Medical Publen_US
dc.relation.ispartofTrakya Universitesi Tip Fakultesi Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcetylcysteineen_US
dc.subjectCadmiumen_US
dc.subjectGlutathioneen_US
dc.subjectMelatoninen_US
dc.subjectTaurineen_US
dc.subjectLipid-Peroxidationen_US
dc.subjectOxidative Stressen_US
dc.subjectInduced Hepatotoxicityen_US
dc.subjectReactive Oxygenen_US
dc.subjectToxicityen_US
dc.subjectEnzymesen_US
dc.subjectKidneyen_US
dc.subjectRatsen_US
dc.subjectAmeliorationen_US
dc.subjectInflammationen_US
dc.titleThe antioxidant effects of taurine, melatonin and N-acetylcysteine in cadmium-induced lung injuryen_US
dc.typeArticleen_US

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