Sister chromatid exchanges in lymphocytes of nuclear medicine physicians

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dc.authoridPalanduz, Sukru/0000-0002-9435-009X;
dc.authorwosidPalanduz, Sukru/AAC-6863-2020
dc.authorwosidOguz, Fatma/AAD-2962-2020
dc.authorwosidBozkurt, Gulcin/A-7599-2018
dc.contributor.authorBozkurt, G
dc.contributor.authorYuksel, M
dc.contributor.authorKarabogaz, G
dc.contributor.authorSut, N
dc.contributor.authorSavran, FO
dc.contributor.authorPalanduz, S
dc.contributor.authorYigitbasi, ON
dc.date.accessioned2024-06-12T11:09:27Z
dc.date.available2024-06-12T11:09:27Z
dc.date.issued2003
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The aim of this study was to assess whether occupational exposure to chronic, low doses of Iodine 131 (I-131) and Technetium 99m (Tc-99m) may lead to genotoxicity. Medical personnel occupied in nuclear medicine departments are occupationally exposed to low doses of I-131 and Tc-99m. The determination of the frequency of sister chromatid exchanges (SCEs) and of cells with a high frequency of SCEs (HFC) is considered to be a sensitive indicator for detecting genotoxic potential of mutagenic and carcinogenic agents. Therefore, we examined peripheral lymphocytes from nuclear medicine physicians for the presence of both SCE and HFC. Methods: Sixteen exposed nuclear medicine physicians (non-smokers) were compared to 16 physicians (non-smokers) who had not been exposed to chemical or physical mutagens in their usual working environment at the same hospital. Results: A statistically significant difference was found between SCE frequencies and HFC percentages measured in lymphocytes from the exposed and control groups. Conclusions: The present observation on the effect of chronic low doses of I-131 and Tc-99m indicates the possibility of genotoxic implications of this type of occupational exposure. Hence, the personnel who work in nuclear medicine departments should carefully apply the radiation protection procedures and should minimize, as low as possible, radiation exposure to avoid possible genotoxic effects. (C) 2002 Elsevier Science B.V. All rights reserved.en_US
dc.identifier.doi10.1016/S1383-5718(02)00321-2
dc.identifier.endpage213en_US
dc.identifier.issn1383-5718
dc.identifier.issue2en_US
dc.identifier.pmid12581539en_US
dc.identifier.scopus2-s2.0-0037416775en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage205en_US
dc.identifier.urihttps://doi.org/10.1016/S1383-5718(02)00321-2
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22801
dc.identifier.volume535en_US
dc.identifier.wosWOS:000181130400011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Bven_US
dc.relation.ispartofMutation Research-Genetic Toxicology And Environmental Mutagenesisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNuclear Medicineen_US
dc.subjectGenotoxicityen_US
dc.subjectSister Chromatid Exchangeen_US
dc.subjectOccupational Exposureen_US
dc.subjectPeripheral-Blood Lymphocytesen_US
dc.subjectIonizing-Radiationen_US
dc.subjectAlpha-Particlesen_US
dc.subjectUranium Minersen_US
dc.subjectCellsen_US
dc.subjectFrequencyen_US
dc.subjectExposureen_US
dc.subjectInductionen_US
dc.subjectSceen_US
dc.subjectDnaen_US
dc.titleSister chromatid exchanges in lymphocytes of nuclear medicine physiciansen_US
dc.typeArticleen_US

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