The -31 G/C promoter gene polymorphism of survivin in Turkish patients with colorectal cancer

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dc.authorwosidBudak, metin/Z-3010-2019
dc.authorwosidErdamar, Sibel/X-5511-2018
dc.authorwosidTUNCEL, HANDAN/C-7303-2019
dc.contributor.authorBudak, M.
dc.contributor.authorBozkurt, C.
dc.contributor.authorCetin, S. E.
dc.contributor.authorTuncel, H.
dc.date.accessioned2024-06-12T11:17:35Z
dc.date.available2024-06-12T11:17:35Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction Survivin (also known as birc5) is the first protein discovered among the apoptosis-regulating gene family referred to as inhibitor of apoptosis proteins (IAPs). It is expressed and controlled during cellular differentiation and development in human beings. Survivin expression has been shown in a number of cancers and has been associated with cancer development. Objective In our study, we compared normal and tumoural tissue samples, which were obtained from 100 patients diagnosed with colorectal cancer, at Department of Pathology, Istanbul University. Methods The present study employed PCR-RFLP to identify the -31 G/C polymorphism in the promoter region of the survivin gene. Distribution of the survivin polymorphism was compared between control and tumoural tissue samples using the chi-square test. Results Comparison of all samples revealed that there was significant difference in distribution of survivin promoter -31G/C between tumour and normal tissue of the patient group (p<0.05). When genotypes were compared according to gender, there was no statistically significant difference in the distribution of survivin promoter -31G/C in females p=0.420 or males p=0.309. Conclusion A significant difference was seen in distribution of C allele in tumour tissue compared to normal tissue.en_US
dc.identifier.doi10.4038/cmj.v63i3.8714
dc.identifier.endpage155en_US
dc.identifier.issn0009-0875
dc.identifier.issue3en_US
dc.identifier.startpage151en_US
dc.identifier.urihttps://doi.org/10.4038/cmj.v63i3.8714
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24768
dc.identifier.volume63en_US
dc.identifier.wosWOS:000445912400010en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherSri Lanka Medical Assocen_US
dc.relation.ispartofCeylon Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAntiapoptosis Geneen_US
dc.subjectRisken_US
dc.subjectExpressionen_US
dc.titleThe -31 G/C promoter gene polymorphism of survivin in Turkish patients with colorectal canceren_US
dc.typeArticleen_US

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