The Determination of Single and Mixture Toxicity at High Concentrations of Some Acidic Pharmaceuticals via Aliivibrio fischeri

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dc.authoridDokmeci, Ayse/0000-0002-4439-4422
dc.authorwosidDokmeci, Ayse/H-7591-2012
dc.contributor.authorDokmeci, Ayse Handan
dc.contributor.authorDokmeci, Ismet
dc.contributor.authorIbar, Hilmi
dc.date.accessioned2024-06-12T11:03:39Z
dc.date.available2024-06-12T11:03:39Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractPharmaceutical and Personal Care Products (PPCPs) may cause serious and significant environmental pollution. Environmental analyses have detected pharmaceuticals in addition to conventional chemical pollutants. In our study, the acute toxicity of ibuprofen, naproxen, diclofenac, salicylic acid and substances that are mixtures themselves (INDS) on Aliivibrio fischeri bacterium were assessed with the use of ToxAlert (R). The selected materials are acidic in nature, highly polarized and widely sold over-the-counter analgesics. Dose-response curves were drawn, and linear regression analyses and probit analyses determined their 50 %-effective concentrations (EC50). The pharmaceuticals alone are unlikely to have acute impacts in aquatic environments. However, when evaluated in combination with A. fischeri bacterium, the acute toxicity of the INDS mixture was EC50 7.09 +/- 5.1 mg/L and the acute toxicity of TUs was 14.10, which indicates their very toxic quality for organisms. Since the target components do not exist in isolation, we should primarily consider the toxicity of the mixture only at high concentrations.en_US
dc.description.sponsorshipTrakya University Scientific Research Project [TUBAP-120]en_US
dc.description.sponsorshipThis study was supported by Trakya University Scientific Research Project TUBAP-120. The authors are grateful to the TUBITAK Marmara Research Center for conducting the toxicity measurements. An initial version of this paper was presented at the 8th International Conference of the EWRA in Porto, Portugal, June 26-29, 2013.en_US
dc.identifier.doi10.1007/s40710-014-0009-7
dc.identifier.endpage103en_US
dc.identifier.issn2198-7491
dc.identifier.issn2198-7505
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84950349938en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage95en_US
dc.identifier.urihttps://doi.org/10.1007/s40710-014-0009-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21738
dc.identifier.volume1en_US
dc.identifier.wosWOS:000434725600001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSpringer International Publishing Agen_US
dc.relation.ispartofEnvironmental Processes-An International Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectIbuprofenen_US
dc.subjectNaproxenen_US
dc.subjectDiclofenacen_US
dc.subjectSalicylic Aciden_US
dc.subjectMixture Toxicityen_US
dc.subjectAliivibrio Fischerien_US
dc.titleThe Determination of Single and Mixture Toxicity at High Concentrations of Some Acidic Pharmaceuticals via Aliivibrio fischerien_US
dc.typeArticleen_US

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