Irbesartan has a masking effect on dipyridamole stress induced myocardial perfusion defects

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386;
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.authorwosidYildiz, Mustafa/D-6892-2019
dc.contributor.authorAltun, GD
dc.contributor.authorAltun, A
dc.contributor.authorYildiz, M
dc.contributor.authorFirat, MF
dc.contributor.authorHacimahmutoglu, S
dc.contributor.authorBerkarda, S
dc.date.accessioned2024-06-12T11:07:16Z
dc.date.available2024-06-12T11:07:16Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and aim The angiotensin 11 type 1 (AT(1)) receptor antagonist irbesartan is used for the treatment of hypertension, but its anti-ischaemic effect is not yet known. Our aim was to assess the effect of irbesartan administration on the diagnostic yield of Tc-99m sestamibi single photon emission computed tomography (SPECT) in patients with coronary artery disease (CAD) after dipyridamole stress. Methods Our study group consisted of 13 patients (11 men and two women; mean age, 53.3 +/- 10.6 years; body mass index, 26.9 +/- 3.3 kg.m(-2)) with angiographically documented CAD. All patients underwent Tc-9m sestamibi SPECT studies at rest, before (STRESS-1) and 2 weeks after irbesartan (150 mg daily) administration (STRESS-2) at dipyridamole stress. The extent and severity of defects were analysed by using visual and quantitative Tc-99m sestamibi SPECT. Results The mean summed stress score was significantly higher during the STRESS-1 study than the STRESS-2 study (13.2 +/- 7.4 vs. 11 +/- 74, P=0.003). The mean size of perfusion defects at stress was significantly larger for the STRESS-1 group than the STRESS-2 group (17.8% +/- 2.85% vs. 15.3% +/- 2.95%, P=0.01). Conclusion Our study showed that the AT(1) receptor blocker irbesartan reduces the extent and severity of Tc-99m sestamibi perfusion defects after dipyridamole stress in patients with CAD. Irbesartan may alter coronary blood flow reserve. The continued use of irbesartan before stress myocardial perfusion SPECT has a masking effect on stress induced myocardial perfusion defects. For this reason AT(1) receptor blockers must be stopped before stress myocardial perfusion scintigraphic examinations. (C) 2004 Lippincott Williams Wilkins.en_US
dc.identifier.doi10.1097/00006231-200402000-00017
dc.identifier.endpage199en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue2en_US
dc.identifier.pmid15154711en_US
dc.identifier.scopus2-s2.0-1542344994en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage195en_US
dc.identifier.urihttps://doi.org/10.1097/00006231-200402000-00017
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21976
dc.identifier.volume25en_US
dc.identifier.wosWOS:000220962600017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIrbesartanen_US
dc.subjectMyocardial Perfusionen_US
dc.subjectIschaemiaen_US
dc.subjectTc-99m Sestamibien_US
dc.subjectCoronary-Artery-Diseaseen_US
dc.subjectReceptor Blockadeen_US
dc.subjectHearten_US
dc.subjectSeverityen_US
dc.subjectExerciseen_US
dc.subjectExtenten_US
dc.subjectStateen_US
dc.titleIrbesartan has a masking effect on dipyridamole stress induced myocardial perfusion defectsen_US
dc.typeArticleen_US

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