Silent myocardial ischemia in middle-aged asymptomatic patients with type 2 diabetes in Turkish population

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorUgur-Altun, Betul
dc.contributor.authorAltun, Armagan
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorTatli, Ersan
dc.contributor.authorKara, Mujdat
dc.contributor.authorTugrul, Armagan
dc.date.accessioned2024-06-12T11:19:02Z
dc.date.available2024-06-12T11:19:02Z
dc.date.issued2007
dc.departmentTrakya Üniversitesien_US
dc.description194th Meeting of the Society-for-Endocrinology -- NOV, 2003 -- London, ENGLANDen_US
dc.description.abstractThe authors investigated silent myocardial ischemia in unselected consecutive middle-aged asymptomatic patients with type 2 diabetes without any evidence of coronary heart disease documented by treadmill exercise test. Ninety asymptomatic patients with type 2 diabetes (48 men; mean age; 49 +/- 6 years) were included in the study. Mean duration of diabetes in the study group was 4 +/- 4.2 years (range 1 to 21 years); 38% of the study population, diabetes duration was only 1 year). All patients were subjected to treadmill exercise test with Bruce protocol. A positive test was noted in 4 of 90 (4%) study patients. Two male patients (4%) and 2 (4%) women patients developed exercise-induced ST-segment depression, but none had concomitant chest pain. Diabetics with silent myocardial ischemia were older (55 +/- 3 years vs 49 +/- 6 years, p = 0.04) than those without silent myocardial ischemia. Also, diabetics with silent myocardial ischemia had higher fibrinogen level (372 +/- 51 vs 307 +/- 71 mg/dL, p = 0.04) than diabetics without silent myocardial ischemia. In treadmill exercise test, diabetics with silent myocardial ischemia had lower total exercise time and peak workload (375 +/- 30 vs 474 +/- 115 seconds, p = 0.04; 7.3 +/- 0.5 vs 8.9 +/- 1.9, p = 0.04, respectively) than without silent myocardial ischemia. Insulin resistance is associated with a variety of atherosclerosis risk factors. Exercise test findings show increased cardiac sympathetic activity and parasympathetic withdrawal in increased insulin resistance.en_US
dc.description.sponsorshipSoc Endocrinolen_US
dc.identifier.doi10.1177/0003319707307765
dc.identifier.endpage542en_US
dc.identifier.issn0003-3197
dc.identifier.issn1940-1574
dc.identifier.issue5en_US
dc.identifier.pmid18024935en_US
dc.identifier.scopus2-s2.0-35448938055en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage535en_US
dc.identifier.urihttps://doi.org/10.1177/0003319707307765
dc.identifier.urihttps://hdl.handle.net/20.500.14551/25062
dc.identifier.volume58en_US
dc.identifier.wosWOS:000250393000003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofAngiologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHomeostasis Model Assessmenten_US
dc.subjectInsulin-Resistanceen_US
dc.subjectMellitusen_US
dc.subjectDiseaseen_US
dc.titleSilent myocardial ischemia in middle-aged asymptomatic patients with type 2 diabetes in Turkish populationen_US
dc.typeConference Objecten_US

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