5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice
Küçük Resim Yok
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Pergamon-Elsevier Science Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The role of 5-HT7 receptors in the nociceptive processing received most attention during the last few years. The involvement of 5-HT7 receptors in nerve injury-induced neuropathic pain states have been reported only recently; however, there are no reports on its contribution in diabetic neuropathic pain. We therefore planned to investigate the effect of 5-HT7 receptor activation on the changes of nociceptive threshold in diabetic mice. Diabetes was induced by a single intraperitoneal injection of streptozocin (150 mg/kg, i.p.). The nociceptive responses in normal and diabetic animals were tested in the hot-plate and tail-flick assays. Both hot-plate and tail-flick latencies significantly shortened at 1-3/4 weeks (thermal hyperalgesia) and prolonged at 6-7 weeks (thermal hypoalgesia) after streptozocin administration. At the dose of 10 mg/kg, systemic injections of AS-19, a selective 5-HT7 receptor agonist, reduced thermal hyperalgesia at early stage of diabetes, but did not influence thermal hypoalgesia at late stage. Co-administration of SB-258719, a selective 5-HT7 receptor antagonist, at a dose that had no effect on its own (10 mg/kg), reversed the anti-hyperalgesic effect of AS-19. Our results indicate that systemic administration of 5-HT7 receptor agonists may have clinical utility in treating diabetic neuropathic pain. (C) 2012 Elsevier Inc. All rights reserved.
Açıklama
14th World Congress on Pain -- AUG 27-31, 2012 -- Milan, ITALY
Anahtar Kelimeler
Diabetes, Thermal Hyperalgesia, Thermal Hypoalgesia, Serotonin, 5-HT7 Receptors, Descending Serotonergic Pathways, Spinal 5-Ht7, Tactile Allodynia, Neuropathic Pain, Model, Antinociception, Pathogenesis, Rats
Kaynak
Pharmacology Biochemistry And Behavior
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Cilt
102
Sayı
2
