Investigation of the Relationship Between MTHFR C677T Gene Variation and Serum Copper Levels in Patients Diagnosed with Parkinson's

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dc.contributor.authorAy, Arzu
dc.contributor.authorAlkanlı, Nevra
dc.contributor.authorGüler, Sibel
dc.date.accessioned2024-06-12T10:05:39Z
dc.date.available2024-06-12T10:05:39Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: In this study, we aimed to investigation of the relationship between MTHFR C677T gene variation and serum copper levels in patients diagnosed with Parkinson's. Materials and Methods: For our study, patient and control groups were formed including 63 Parkinson's patients and 32 healthy controls. Genotype distributions for MTHFR gene variation were determined and serum copper levels were measured. In these processes PCR, RFLP and atomic absorption spectrophotometer methods were applied. Results: Serum Cu levels of Parkinson's patients were found to be significantly higher than healthy controls. Although the significant difference was not found between the patient and control groups in terms of genotype distributions of the MTHFR C677T gene variation, CC homozygote genotype of this gene variation was observed significantly more than other genotypes in the patient group. In addition, the C allele frequency of this gene variation was determined significantly different from the Hardy-Weinberg distribution in Parkinson's patients. Serum copper levels of Parkinson's patients carrying CT and TT genotypes were detected significantly higher than the serum copper levels of controls carrying the same genotypes. Conclusion: In our study, in Thrace population, it was determined that the relationship between MTHFR C677T gene variation and serum copper levels may be an important factor for Parkinson's disease. In conclusion, the evaluation of MTHFR C677T gene variation genotype distributions and serum copper levels together is extremely important for prognosis of Parkinson's disease.en_US
dc.identifier.doi10.5505/vtd.2022.44712
dc.identifier.endpage253en_US
dc.identifier.issn1300-2694
dc.identifier.issn2587-0351
dc.identifier.issue3en_US
dc.identifier.startpage246en_US
dc.identifier.trdizinid1124249en_US]
dc.identifier.urihttps://doi.org/10.5505/vtd.2022.44712
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/1124249
dc.identifier.urihttps://hdl.handle.net/20.500.14551/13576
dc.identifier.volume29en_US
dc.indekslendigikaynakTR-Dizinen_US
dc.language.isoenen_US
dc.relation.ispartofVan Tıp Dergisien_US
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleInvestigation of the Relationship Between MTHFR C677T Gene Variation and Serum Copper Levels in Patients Diagnosed with Parkinson'sen_US
dc.typeArticleen_US

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