Effects of Estrogen on Coronary Artery Calcification and the Relationship Between Osteoporosis and Cardiovascular Diseases in Postmenopausal Women

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dc.contributor.authorGüvenç, Alican
dc.contributor.authorYılmaz, Ceren
dc.contributor.authorBalta, Buse
dc.contributor.authorYıldız, Zeynep
dc.contributor.authorVardar, Selma Arzu
dc.date.accessioned2021-11-20T10:27:22Z
dc.date.available2021-11-20T10:27:22Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Anabilim Dalıen_US
dc.description.abstractEstrogen deficiency is known to be one of the causes of cardiovascular disease and osteoporosis in postmenopausal women. Coronary artery calcification is one of the major factors of cardiovascular disease. The studies related to the effects of estrogen on coronary artery calcification and the possible relation between osteoporosis and cardiovascular disease rapidly increased in recent years. Estrogen levels decrease in postmenopausal women and can lead to an increased risk of cardiovascular disease. Estrogen could affect cardiovascular diseases by mediating the receptor activator of nuclear factor-kappa B ligand-osteoprotegerin system in vascular smooth muscle cells and autophagy in cardiomyocytes. Current evidence indicates that estrogen has an increasing effect on bone mineral density by multiple biochemical pathways: increasing calcium absorption in the gastrointestinal system, decreasing excretion of calcium in the kidneys, reducing bone resorption, such as enchanting osteoblasts, suppressing osteoclasts by inhibiting proinflammatory cytokines, and inhibiting the activity of osteoclasts by essentially inhibiting the receptor activator of nuclear factor-kappa B ligand-osteoprotegerin system. Recent studies showed a significant relationship between coronary artery calcification and osteoporosis due to estrogen’s role in these pathogeneses, which can be prevented by using estrogen hormone therapy for post- menopausal women. In this review, we focused on the molecular mechanisms of estrogen in the development of coronary artery calcification and osteoporosis and the effects of estrogen hormone therapy on cardiovascular diseases in postmenopausal women.en_US
dc.identifier.dergipark1020947en_US
dc.identifier.endpage102en_US
dc.identifier.issn2148-4724
dc.identifier.issn2548-0030
dc.identifier.issue3en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://dergipark.org.tr/tr/pub/tmsj/issue/65735/1020947
dc.identifier.urihttps://dergipark.org.tr/tr/download/article-file/2070910
dc.identifier.urihttps://hdl.handle.net/20.500.14551/6343
dc.identifier.volume8en_US
dc.language.isoenen_US
dc.publisherTrakya Üniversitesien_US
dc.relation.ispartofTurkish Medical Student Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectMenopauseen_US
dc.subjectosteoporosisen_US
dc.subjectvascular calcificationen_US
dc.subjectestrogen replacement therapyen_US
dc.subjectcardiovascular diseasesen_US
dc.titleEffects of Estrogen on Coronary Artery Calcification and the Relationship Between Osteoporosis and Cardiovascular Diseases in Postmenopausal Womenen_US
dc.typeArticleen_US

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