Electron Microscopic Evaluation of the Secretory Mechanisms of Renin from Juxtaglomerular Cells

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dc.authoridAktas, Ranan/0000-0002-4474-7371
dc.authorwosidAktas, Ranan/F-2910-2016
dc.contributor.authorAktas, Ranan Gulhan
dc.contributor.authorKarabay, Gulten
dc.contributor.authorTaskinalp, Oguz
dc.contributor.authorKutlu, A. Kemal
dc.date.accessioned2024-06-12T11:07:23Z
dc.date.available2024-06-12T11:07:23Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAlthough the structure and the functions of juxtaglomerular cells (JG) have been well defined, there is still a controversy about the secretory mechanisms of renin from these cells. It has been assumed that exocytosis is the main secretory mechanism in these cells in many studies, while others suggest that secretion occurs in a quite different way in these cells. There are several studies suggesting that diacrine secretion, which is very difficult to visualize, might be the other mechanism for secretion of renin. This study is an attempt to find the answers of these questions by identifying the fine structural features of the secretory granules in juxtaglomerular cells. Cyclosporin A (CyA) has been used in the current experimental study since it has already been reported that this drug increases the number of JG cells and stimulates secretion of Renin. Twelve female Sprague-Dawley rats had daily intraperitoneal injections of CyA for ten weeks. Tissue specimens from the kidneys of these animals were examined by electron microscopy. Fine structural characteristics of the secretory granules of juxtaglomerular cells have been examined. Considerable amount of granules, which goes to the exocytotic process, have been observed. Additionally, several cells, which their granules had been secreting their contents in a different way, were found. This was interpreted as the secretion type of diacrine secretion. In conclusion, this in vivo study presents morphologic evidences demonstrating that both exocytosis and diacrine secretion might occur in JG cells. We also had a chance to observe secretory granule probably exhibiting diacrine secretion, which is very difficult to visualize, at electron microscope level for the first time. This report also provides morphologic proof which shows that these two distinct secretory mechanisms might occur simultaneously in the same juxtaglomerular cell.en_US
dc.identifier.endpage728en_US
dc.identifier.issn0717-9502
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-78649381745en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage723en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21999
dc.identifier.volume28en_US
dc.identifier.wosWOS:000283274500011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSoc Chilena Anatomiaen_US
dc.relation.ispartofInternational Journal Of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectJuxtaglomerular Cellsen_US
dc.subjectSecretory Granulesen_US
dc.subjectMicroscopyen_US
dc.subjectExocytosisen_US
dc.subjectReleaseen_US
dc.subjectGranulesen_US
dc.subjectKidneyen_US
dc.subjectSystemen_US
dc.titleElectron Microscopic Evaluation of the Secretory Mechanisms of Renin from Juxtaglomerular Cellsen_US
dc.typeArticleen_US

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