Vancomycin-resistant enterococci infection and predisposing factors for infection and mortality in patients with acute leukaemia and febrile neutropenia

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dc.authoridAlp Kirkizlar, Tugcan/0000-0002-1361-6213
dc.authoridKirkizlar, Onur/0000-0001-7523-8599
dc.authoridÖzakın, Cüneyt/0000-0001-5428-3630;
dc.authorwosidAlp Kirkizlar, Tugcan/HMD-4249-2023
dc.authorwosidKAZAK, Esra/AAG-8459-2021
dc.authorwosidAlp Kirkizlar, Tugcan/AAI-5246-2020
dc.authorwosidKirkizlar, Onur/W-9594-2018
dc.authorwosidOzkocaman, Vildan/AAH-1854-2021
dc.authorwosidAkalin, Halis/AAU-8952-2020
dc.authorwosidÖzakın, Cüneyt/AAG-8392-2021
dc.contributor.authorKirkizlar, Tugcan Alp
dc.contributor.authorAkalin, Halis
dc.contributor.authorKirkizlar, Onur
dc.contributor.authorOzkalemkas, Fahir
dc.contributor.authorOzkocaman, Vildan
dc.contributor.authorKazak, Esra
dc.contributor.authorOzakin, Cuneyt
dc.date.accessioned2024-06-12T11:17:01Z
dc.date.available2024-06-12T11:17:01Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: Vancomycin-resistant enterococcus (VRE) is an infectious agent that can increase morbidity and mortality, especially in patients with neutropenia in haematology departments. We analysed VRE infections and mortality rates among VRE colonized patients with acute leukaemia, defined predisposing risk factors for infection and mortality, and investigated the influence of daptomycin or linezolid treatment on mortality. Patients-Methods: We included 200 VRE colonized adult acute leukaemia patients with febrile neutropenia between January 2010 and January 2016. Data were collected from electronic files. Results: There were 179 patients in the colonized group, and 21 patients in the infected group. Enterococcus faecium (van A) was isolated from all patients. The infection rate was 10.5 %, and the types of infections noted were as follows: bloodstream (n = 14; 66.7 %), skin and soft tissue (n = 3; 14.3 %), urinary (n = 2; 9.5 %), and others (9.5 %). In the multivariate logistic regression analysis, exposure to invasive procedures, coinfection status, and 15 days of VRE positivity were independent risk factors for VRE infections. In hospital mortality rates were 57.1 % in the infected group, and 9.5 % in the colonized group (p < 0.001). Older age, female gender, absolute neutropenia, and coinfection status were statistically significant predictor of survival. Conclusion: Vancomycin-resistant enterococcus infections are associated with high morbidity and mortality in haematology patients with neutropenia. Clinicians should be aware of predisposing risk factors for VRE infection to avoid unfavourable outcomes. We believe that larger studies are necessary regarding the influence of treatment with daptomycin and linezolid.en_US
dc.identifier.doi10.1016/j.leukres.2020.106463
dc.identifier.issn0145-2126
dc.identifier.issn1873-5835
dc.identifier.pmid33130331en_US
dc.identifier.scopus2-s2.0-85093655706en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.leukres.2020.106463
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24548
dc.identifier.volume99en_US
dc.identifier.wosWOS:000595869800011en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofLeukemia Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVancomycin-Resistant Enterococcusen_US
dc.subjectAcute Leukaemiaen_US
dc.subjectFebrile Neutropeniaen_US
dc.subjectRisk Factorsen_US
dc.subjectDaptomycinen_US
dc.subjectLinezoliden_US
dc.titleVancomycin-resistant enterococci infection and predisposing factors for infection and mortality in patients with acute leukaemia and febrile neutropeniaen_US
dc.typeArticleen_US

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