Nebulized surfactant as a treatment choice for otitis media with effusion: an experimental study in the rabbit

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dc.authoridUZUN, CEM/0000-0003-3233-7049
dc.authorwosidUZUN, CEM/K-3307-2012
dc.contributor.authorKoten, M
dc.contributor.authorUzun, C
dc.contributor.authorYagiz, R
dc.contributor.authorKemal, M
dc.contributor.authorAdali, K
dc.contributor.authorKarasalihoglu, AR
dc.contributor.authorTatman-Otkun, M
dc.date.accessioned2024-06-12T11:11:48Z
dc.date.available2024-06-12T11:11:48Z
dc.date.issued2001
dc.departmentTrakya Üniversitesien_US
dc.description2nd Seminar on Otology and Neuro-Otology -- MAY 19-20, 2000 -- STARA ZAGORA, BULGARIAen_US
dc.description.abstractExogenous surfactant can improve eustachian tube function in experimentally induced otitis media with effusion (OME). Performing tympanometric recordings, the efficacy of inhaled nebulized surfactant, as compared with inhaled nebulized physiological saline was investigated, for the treatment of OME experimentally induced in the rabbit by intrabullar inoculation of heat-killed Streptococcus pneumoniae. In addition, the histological changes in middle ears after the treatment were investigated in order to establish whether the pathological findings correlated with the results. Middle-ear pressure values before, and after, treatment were analyzed by the Wilcoxon statistical method, and the Mann-Whitney U test was used to compare the post-treatment values between groups. In all ears with OME in the affected animals, which were treated with nebulized surfactant inhalation, a positively significant (p <0.05) increase of pressure more than 20 daPa was recorded. In the control group, after inhalation of nebulized physiological saline, there was no positive increase in the affected middle-ear pressures; on the contrary, more negative pressure changes were recorded. In the histological evaluation, middle-ear epithelia and sub-epithelial space were normal in surfactant-treated ears with OME, whereas mucosal thickening with an oedematous sub-epithelial space containing occasional inflammatory cells and increases in connective tissue and vascularity, and effusions on the epithelial surface were present in the ears with OME in the control group. The significant improvement in the negative middle-ear pressure after nebulized surfactant treatment and the histological findings shown in our study can support the theory that surface-active agents are of importance in eustachian tube function even under pathologic conditions, such as OME.en_US
dc.identifier.doi10.1258/0022215011907848
dc.identifier.endpage368en_US
dc.identifier.issn0022-2151
dc.identifier.issn1748-5460
dc.identifier.issue5en_US
dc.identifier.pmid11410125en_US
dc.identifier.scopus2-s2.0-0034769740en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage363en_US
dc.identifier.urihttps://doi.org/10.1258/0022215011907848
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22938
dc.identifier.volume115en_US
dc.identifier.wosWOS:000168972200002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofJournal Of Laryngology And Otologyen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectOtitis Media With Effusionen_US
dc.subjectSurface-Active Agentsen_US
dc.subjectTherapyen_US
dc.subjectInhalation Exposureen_US
dc.subjectRabbitsen_US
dc.subjectTension-Lowering Substanceen_US
dc.subjectEustachian-Tube Functionen_US
dc.subjectMiddle-Earen_US
dc.subjectActive Substancesen_US
dc.subjectTubotympanumen_US
dc.titleNebulized surfactant as a treatment choice for otitis media with effusion: an experimental study in the rabbiten_US
dc.typeConference Objecten_US

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