Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats

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dc.authoridYALCIN, OMER TARIK/0000-0001-5626-1881
dc.authoridbasaran, umit nusret/0000-0002-9977-6655
dc.authorwosidAktas, Cevat/D-8468-2011
dc.authorwosidGuzel, Ahmet/AGE-2880-2022
dc.authorwosidYALCIN, OMER TARIK/B-4744-2018
dc.contributor.authorGuzel, Ahmet
dc.contributor.authorBasaran, Umit Nusret
dc.contributor.authorAksu, Burhan
dc.contributor.authorKanter, Mehmet
dc.contributor.authorYalcin, Omer
dc.contributor.authorAktas, Cevat
dc.contributor.authorGuzel, Aygul
dc.date.accessioned2024-06-12T11:13:07Z
dc.date.available2024-06-12T11:13:07Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: The aim of this study was to evaluate the efficiency of inducible nitric oxide synthase (iNOS) specific inhibitor, S-methylisothiourea sulfate (SMT) in preventing lung injury after different pulmonary aspiration materials in rats. Material and methods: The experiments were performed in 80 Sprague-Dawley rats, ranging in weight from 220 to 250 g, randomly allotted into one of the eight groups (n = 10): normal saline (NS, control), Biosorb Energy Plus (BIO), sucralfate (SUC), hydrochloric acid (HCl), NS + SMT treated, BIO + SMT treated, SUC + SMT treated, and HCl + SMT treated. NS, BIO, SUC, HCl were injected in to the Lungs in a volume of 2 ml/kg. The rats received twice daily intraperitoneal injections of 20 mg(kg day) SMT (Sigma Chemical Co.) for 7 days. Seven days Later, rats were killed, and both lungs in all groups were examined immunohistochemically and histopathologically. Results: Our data show that SMT inhibits the inflammatory response significantly reducing (p < 0.05) peribronchial inflammatory cell infiltration, alveolar septal, infiltration, alveolar edema, alveolar exudate, alveolar histiocytes, interstitial fibrosis, granuloma, and necrosis formation in different pulmonary aspiration models. Furthermore, our data suggest that there is a significant reduction in the activity of MOS and arise in the expression of surfactant protein D in lung tissue of different pulmonary aspiration models with SMT therapy. Conclusion: it was concluded that SMT treatment might be beneficial in Lung injury, therefore shows potential for clinical use. Crown Copyright (c) 2008 Published by Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijporl.2008.05.001
dc.identifier.endpage1250en_US
dc.identifier.issn0165-5876
dc.identifier.issn1872-8464
dc.identifier.issue8en_US
dc.identifier.pmid18573544en_US
dc.identifier.scopus2-s2.0-46049089974en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1241en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijporl.2008.05.001
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23431
dc.identifier.volume72en_US
dc.identifier.wosWOS:000258015800014en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Pediatric Otorhinolaryngologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPulmonary Aspirationen_US
dc.subjectAcute Lung Injuryen_US
dc.subjectSurfactant Protein Den_US
dc.subjectInosen_US
dc.subjectS-Methylisothiourea Sulfateen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectRespiratory-Distress Syndromeen_US
dc.subjectNecrosis-Factor-Alphaen_US
dc.subjectAcid Aspirationen_US
dc.subjectTracheobronchial Aspirationen_US
dc.subjectPulmonary Aspirationen_US
dc.subjectHydrochloric Aciden_US
dc.subjectL-Arginineen_US
dc.subjectProtein-Den_US
dc.subjectMiceen_US
dc.titleProtective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in ratsen_US
dc.typeArticleen_US

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