Antimicrobial and toxicity profiles evaluation of the Chamomile (Matricaria recutita L.) essential oil combination with standard antimicrobial agents

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dc.authoridhttp://orcid.org/0000-0003-2978-5385en_US
dc.contributor.authorGoger, Gamze
dc.contributor.authorDemirci, Betul
dc.contributor.authorIlgin, Sinem
dc.contributor.authorDemirci, Fatih
dc.date.accessioned2019-06-24T15:02:17Z
dc.date.available2019-06-24T15:02:17Z
dc.date.issued2018
dc.departmentFakülteler, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractIn this present study, commercial Pharmacopeia (PhEur) grade chamomile essential oil (Mairicariae aetheroleurn) was combined with different antimicrobial agents including ampicillin sodium, cefuroxime acetyl, tetracycline hydrochloride, fluconazole and nystatin. All combinations were evaluated in vitro against pathogenic standard and clinical resistant Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) bacterial isolates as well as against Candida albicans for their broad antimicrobial effectiveness. Furthermore, the essential oil was fractioned by column chromatography using n-hexane, diethyl ether, dichloromethane and methanol, respectively. Additionally, all fractions of essential oil were tested in combinations for their minimum inhibitory concentrations (MIC) as well as for their fractional inhibitory concentrations (FIC) against the resistant microbial pathogens. Antimicrobial activities were evaluated by microdilution method and antimicrobial interactions were assayed using the checkerboard method. Cytotoxicity of compounds were evaluated using Cytotox-XTT-1 1:rameter Kit in WS1 cells and Aliivibrio fischeri bioluminescence toxicity assay. The analyses proved that alpha-bisabolol oxide A (47.7%), (E)-beta-famesene (21.5%), alpha-bisabolol oxide B (6.2%), alpha-bisabolone oxide A (5.8%), chamazulene (4.1%) and alpha-bisabolol (2.2%), respectively were the major compounds and in compliance with PhEur. The essential oil combination of fluconazole and nystatin showed "synergic and additive inhibitory effects" against the clinical Candida strain. According to the IC50 values obtained, the inhibitory concentrations of combinations against the clinical Candida strain can be considered to be selective when compared with its effect on WS1 cells. Additionally, the essential oil combination of fluconazole and nystatin showed low toxicity against A. fischeri.en_US
dc.identifier.citationGöger, G., Demirci, B., Ilgın, S., & Demirci, F. (2018). Antimicrobial and toxicity profiles evaluation of the chamomile (Matricaria recutita L.) essential oil combination with standard antimicrobial agents. Industrial Crops and Products, 120, 279-285.en_US
dc.identifier.doi10.1016/j.indcrop.2018.04.024en_US
dc.identifier.endpage285en_US
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.scopus2-s2.0-85046156144en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://doi.org/10.1016/j.indcrop.2018.04.024
dc.identifier.urihttps://hdl.handle.net/20.500.14551/4969
dc.identifier.volume120en_US
dc.identifier.wosWOS:000434745000032en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb fo Sciencesen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherELSEVIER SCIENCE BVen_US
dc.relation.ispartofIndustrial Crops and Productsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmz20240608_ID_Qen_US
dc.subjectMatricaria recutita L.en_US
dc.subjectEssential Oilen_US
dc.subjectSynergicen_US
dc.subjectAdditiveen_US
dc.subjectCytotoxic Activityen_US
dc.subjectAliivibrio Fischerien_US
dc.subjectBioluminescence Assayen_US
dc.titleAntimicrobial and toxicity profiles evaluation of the Chamomile (Matricaria recutita L.) essential oil combination with standard antimicrobial agentsen_US
dc.typeArticleen_US

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