Lack of correlation between plasma asymmetric dimethylarginine (ADMA) levels and pain-related behaviors in neuropathic rats

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dc.authoridUlugol, Ahmet/0000-0003-4643-1124
dc.authorwosidUlugol, Ahmet/V-9665-2019
dc.contributor.authorHafizoglu, Emin
dc.contributor.authorUlugol, Ahmet
dc.date.accessioned2024-06-12T11:09:11Z
dc.date.available2024-06-12T11:09:11Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: Recent research has demonstrated elevations of ADMA levels in many cardiovascular and metabolic diseases, and ADMA has also been proposed as a modulator of nociception in opiate tolerance and addiction. The present study was conducted to determine whether increased level of peripheral ADMA is implicated in tactile allodynia in rats with partial tight ligation of the sciatic nerve. Methods: Beginning from the 1st measurement after the ligation, paw withdrawal thresholds significantly reduced compared with duration-matched control animals, indicating that mechanical allodynia developed in sciatic nerve-ligated rats. Results: In both neuropathic and control groups, plasma levels of ADMA, SDMA, L-homoarginine and L-arginine remained unchanged throughout the experiment, and there were no significant differences between two groups in different durations. Conclusion: These results suggest that endogenous plasma ADMA, SDMA, L-homoarginine and L-arginine levels do not change during the different stages of neuropathic duration, and accordingly may not be implicated in tactile allodynia in neuropathic rats. (C) 2011 Elsevier GmbH. All rights reserved.en_US
dc.description.sponsorshipTrakya University Research Council [TUBAP-2008/118]en_US
dc.description.sponsorshipThis work was supported by a Grant from Trakya University Research Council (TUBAP-2008/118). The authors would like to thank Dr. Hakan C. Karadag and Dr. Ozgur Gunduz for their skillful technical assistance and critical comments on the manuscript. The authors have no conflicts of interests to report.en_US
dc.identifier.doi10.1016/j.npbr.2011.09.002
dc.identifier.endpage83en_US
dc.identifier.issn0941-9500
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-82455208942en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage79en_US
dc.identifier.urihttps://doi.org/10.1016/j.npbr.2011.09.002
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22703
dc.identifier.volume17en_US
dc.identifier.wosWOS:000299203000001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherUniversitatsverlag Ulm Gmbhen_US
dc.relation.ispartofNeurology Psychiatry And Brain Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNeuropathyen_US
dc.subjectPainen_US
dc.subjectAllodyniaen_US
dc.subjectNitric Oxideen_US
dc.subjectAsymmetric Dimethylarginineen_US
dc.subjectNitric-Oxide Synthaseen_US
dc.subjectL-Arginine Paradoxen_US
dc.subjectMorphine-Toleranceen_US
dc.subjectEndogenous Inhibitoren_US
dc.subjectDiabetic-Ratsen_US
dc.subjectTactile Allodyniaen_US
dc.subjectMechanismsen_US
dc.subjectModelen_US
dc.subjectMononeuropathyen_US
dc.subjectHyperalgesiaen_US
dc.titleLack of correlation between plasma asymmetric dimethylarginine (ADMA) levels and pain-related behaviors in neuropathic ratsen_US
dc.typeArticleen_US

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