Cytokine response in lower extremity ischaemia/reperfusion

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dc.contributor.authorEge, T
dc.contributor.authorUs, MH
dc.contributor.authorSungun, M
dc.contributor.authorDuran, E
dc.date.accessioned2024-06-12T10:50:31Z
dc.date.available2024-06-12T10:50:31Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe studied the local and systemic concentrations of pro-inflammatory cytokines produced during acute lower extremity ischaemia and following reperfusion in 19 patients undergoing thromboembolectomy of the femoral artery. Blood samples were taken from the femoral vein (local response) and radial artery (systemic response) in the ischaemic (baseline) phase, and 2, 12 and 24 h post-reperfusion. Associated lung injury was measured by the alveolar-arterial (A-a) oxygen gradient and post-reperfusion femoral vein plasma concentrations of creatinine kinase and lactic dehydrogenase were also measured. Local and systemic concentrations of interleukin (IL)-2 receptor and IL-6 (but not IL-1beta) increased significantly after reperfusion. IL-8 concentration increased significantly in the radial artery. The high and progressively increasing concentration of IL-6 in the femoral vein suggests local production. The parallel increase in creatinine kinase concentration and A-a oxygen gradient indicates that IL-6 plays an important role in acute arterial occlusion and reperfusion injury.en_US
dc.identifier.doi10.1177/147323000403200204
dc.identifier.endpage131en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue2en_US
dc.identifier.pmid15080015en_US
dc.identifier.scopus2-s2.0-1642487754en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage124en_US
dc.identifier.urihttps://doi.org/10.1177/147323000403200204
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18035
dc.identifier.volume32en_US
dc.identifier.wosWOS:000220445900004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of International Medical Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Arterial Occlusionen_US
dc.subjectCytokinesen_US
dc.subjectIschaemia/Reperfusionen_US
dc.subjectAlveolar-Arterial Gradienten_US
dc.subjectTumor-Necrosis-Factoren_US
dc.subjectMyocardial Ischemia-Reperfusionen_US
dc.subjectProinflammatory Cytokinesen_US
dc.subjectCardiopulmonary Bypassen_US
dc.subjectLung Injuryen_US
dc.subjectInhibitionen_US
dc.subjectInterleukin-2-Receptoren_US
dc.subjectDysfunctionen_US
dc.subjectExerciseen_US
dc.subjectModelen_US
dc.titleCytokine response in lower extremity ischaemia/reperfusionen_US
dc.typeArticleen_US

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