Retrospective multicenter evaluation of patients diagnosed with mucosal melanoma: a study of Anatolian Society of Medical Oncology

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dc.authoridErcelep, Özlem/0000-0001-5892-3519
dc.authoridUlas, Arife/0000-0003-2918-2592
dc.authoridUysal, Mukremin/0000-0002-8524-0665
dc.authoridYücel, Şebnem/0000-0001-6235-7927
dc.authoridbayoglu, ibrahim vedat/0000-0002-0481-1084
dc.authoridaksoy, asude/0000-0002-5609-9658
dc.authorwosidGumus, Mahmut/HTO-4176-2023
dc.authorwosidGumus, Mahmut/C-7135-2008
dc.authorwosidErcelep, Özlem/AAI-7883-2020
dc.authorwosidUlas, Arife/HGD-4686-2022
dc.authorwosidUysal, Mukremin/B-8956-2014
dc.authorwosidYücel, Şebnem/AAY-6737-2021
dc.authorwosidozcelik, melike/AAS-7557-2020
dc.contributor.authorErcelep, Ozlem
dc.contributor.authorTopcu, Turkan Ozturk
dc.contributor.authorBayoglu, Ibrahim Vedat
dc.contributor.authorEkinci, Ahmet Siyar
dc.contributor.authorKoca, Sinan
dc.contributor.authorKavgaci, Halil
dc.contributor.authorOzcelik, Melike
dc.date.accessioned2024-06-12T11:08:45Z
dc.date.available2024-06-12T11:08:45Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractMucosal melanoma (MM) is a rare type of cancer that differs significantly from cutaneous melanoma. In this study, we aimed to evaluate clinical and demographical characteristics, prognoses and factors influencing survival, treatment alternatives, and features of different subtypes of the patients. The patients were followed up with and treated in different centers due to their diagnoses of MM. We retrospectively analyzed data of 107 patients who were diagnosed with MM in 14 different institutions in Turkey. The mean age of the patients was 64.5 years. Of the patients, 47 % were female and 53 % were male. The median overall survival (OS) was 17 months, and the mean follow-up duration was 27 months. The 2-year survival rate was 42 %, and the 5-year survival rate was 23 %. The best survival rate appeared in those patients with MM in the head-neck region (median survival rate was 27 months, P = 0.034). The most common anatomical site was the head-neck region. In a univariate analysis, variables including age aeyen65 years, the anatomical site of the primary lesion other than head and neck region, the metastatic stage of the disease, high levels of lactate dehydrogenase (LDH), and an Eastern Cooperative Oncology Group Performance Status (ECOG PS) of aeyen1 were found to be associated with poor survival (P < 0.05). However, in a multivariate analysis, only advanced stage disease (HR = 2.70; 95 % CI, 1.64-4.45; P = 0.000) and high LDH levels (HR = 2.31; 95 % CI, 1.40-3.80; P = 0.001) were determined to be adverse prognostic variables. Primary MM presents a more aggressive behavior and offers a poorer prognosis compared to cutaneous melanoma. Because the disease is rarely seen, is heterogeneous, and lacks randomized studies, issues concerning optimal treatment approaches and management and clinical characteristics of the disease have not been clarified yet.en_US
dc.identifier.doi10.1007/s13277-016-5076-0
dc.identifier.endpage12038en_US
dc.identifier.issn1010-4283
dc.identifier.issn1423-0380
dc.identifier.issue9en_US
dc.identifier.pmid27173124en_US
dc.identifier.scopus2-s2.0-84966713063en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage12033en_US
dc.identifier.urihttps://doi.org/10.1007/s13277-016-5076-0
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22559
dc.identifier.volume37en_US
dc.identifier.wosWOS:000387075400046en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofTumor Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMucosal Melanomaen_US
dc.subjectHead And Necken_US
dc.subjectAnorectalen_US
dc.subjectGenitourinaryen_US
dc.subjectMalignant-Melanomaen_US
dc.subjectBraf Mutationsen_US
dc.subjectNoncutaneous Melanomaen_US
dc.subjectHeaden_US
dc.subjectNecken_US
dc.subjectTherapyen_US
dc.subjectRadiotherapyen_US
dc.subjectVulvaen_US
dc.titleRetrospective multicenter evaluation of patients diagnosed with mucosal melanoma: a study of Anatolian Society of Medical Oncologyen_US
dc.typeArticleen_US

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