Effect of fibrin glue and comparison with suture on experimental induction of endometriosis in a rat endometrial autograft model

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dc.contributor.authorBoztosun, A.
dc.contributor.authorOzer, H.
dc.contributor.authorAtilgan, R.
dc.contributor.authorAcmaz, G.
dc.contributor.authorYalta, T.
dc.contributor.authorMuderris, I. I.
dc.contributor.authorYanik, A.
dc.date.accessioned2024-06-12T11:01:54Z
dc.date.available2024-06-12T11:01:54Z
dc.date.issued2012
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The effects of fibrin glue (FG) and suture were investigated and compared with experimental induction in an endometriosis model. Material and Methods: A randomized, controlled, and double-blind study was performed with 25 adult female Wistar Albino rats. Two autologous endometrial grafts were obtained from each of the rats. The endometrial grafts were transplanted by gluing with FG on the right abdominal wall and suturing with only 5/0 prolene on the left in ten rats. Gluing+suturing and after suturing over the covering with FG of the endometrial graft were performed, respectively, on the right and left in another ten rats. Covering with FG glue of the endometrial graft was performed in another five rats. The endometriosis-like lesions and intraperitoneal adhesions were evaluated macroscopically and histopathologically. Results: The mean volume (31.4 +/- 17.3), adhesion (0.8 +/- 0.7) and inflammatory reaction (1.2 +/- 0.7) score of the implants in the group using only FG were significantly lower than in the group using suture [respectively, (49.2 +/- 20.6), (2.4 +/- 0.8), (2.2 +/- 0.8)] (p < 0.05). Conclusions: Our results demonstrate the general feasibility of reproducible and reliable endometrial graft fixation with FG onto the inner abdominal surface in rats. Furthermore, several advantageous characteristics could be demonstrated such as less inflammation and fewer adhesions.en_US
dc.identifier.endpage111en_US
dc.identifier.issn0390-6663
dc.identifier.issue1en_US
dc.identifier.pmid22675967en_US
dc.identifier.scopus2-s2.0-84860853499en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage107en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21073
dc.identifier.volume39en_US
dc.identifier.wosWOS:000301509900024en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherI R O G Canada, Incen_US
dc.relation.ispartofClinical And Experimental Obstetrics & Gynecologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibrin Glueen_US
dc.subjectSuturingen_US
dc.subjectAnimal Modelen_US
dc.subjectEndometriosis Inductionen_US
dc.subjectReductionen_US
dc.subjectAdhesionsen_US
dc.subjectSealanten_US
dc.subjectGraftsen_US
dc.titleEffect of fibrin glue and comparison with suture on experimental induction of endometriosis in a rat endometrial autograft modelen_US
dc.typeArticleen_US

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