Effects of oral, continuous and transdermal cyclic 17-? estradiol and norethindrone acetate replacement therapy on platelet aggregation in postmenopausal women

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dc.authorwosidSAYIN, N. CENK/A-5801-2018
dc.contributor.authorKaplan, PB
dc.contributor.authorGücer, F
dc.contributor.authorSayin, NC
dc.contributor.authorYüce, MA
dc.contributor.authorYardim, T
dc.date.accessioned2024-06-12T11:12:39Z
dc.date.available2024-06-12T11:12:39Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractOBJECTIVE: To evaluate the affects of an oral continuous and transdermal cyclic 17-beta estradiol and norethindrone acetate combination on platelet aggregation in postmenopausal women. STUDY DESIGN: Fifty postmenopausal women were randomly assigned to receive 17-beta estradiol and norethindrone acetate either orally continuously or transdermally cyclically and sequentially. Platelet counts and maximum platelet aggregation rates were measured before and after three months treatment. RESULTS: At three months there were no significant changes in platelet counts or in adenosine diphosphate-induced or epinephrine-induced platelet aggregation rates in either treatment group. CONCLUSION: Hormone replacement treatment with a 17-beta estradiol and norethindrone. acetate combination either orally continuously or transdermally cyclically and sequentially does not affect platelet aggregation in postmenopausal women.en_US
dc.identifier.endpage655en_US
dc.identifier.issn0024-7758
dc.identifier.issn1943-3565
dc.identifier.issue8en_US
dc.identifier.pmid12216432en_US
dc.identifier.startpage651en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23259
dc.identifier.volume47en_US
dc.identifier.wosWOS:000177657900010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofJournal Of Reproductive Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPostmenopausal Hormone Replacementen_US
dc.subjectTherapyen_US
dc.subjectPostmenopauseen_US
dc.subjectPlatelet Aggregationen_US
dc.subjectCardiovascular Risk-Factorsen_US
dc.subjectVenous Thromboembolismen_US
dc.subjectEstrogensen_US
dc.subjectHearten_US
dc.subjectMenopauseen_US
dc.subjectHormonesen_US
dc.subjectDiseaseen_US
dc.subjectUsersen_US
dc.titleEffects of oral, continuous and transdermal cyclic 17-? estradiol and norethindrone acetate replacement therapy on platelet aggregation in postmenopausal womenen_US
dc.typeArticleen_US

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