Can serum Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 help in decision making for surgery in antenatally dedected hydronephrosis

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dc.authoridYiğit, Doğakan/0000-0001-9863-8560
dc.authorwosidTAŞKINLAR, HAKAN/B-1275-2016
dc.authorwosidYiğit, Doğakan/AIA-5267-2022
dc.contributor.authorYigit, Dogakan
dc.contributor.authorTaskinlar, Hakan
dc.contributor.authorAvlan, Dincer
dc.date.accessioned2024-06-12T10:51:52Z
dc.date.available2024-06-12T10:51:52Z
dc.date.issued2021
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIntroduction Congenital obstructive uropathies are among leading reasons for renal failure in children. Answers to questions such as what the critical threshold of obstruction is or which degree of obstruction disrupts the development of the kidney still remain unclear. Several biomarkers such as Kidney Injury Molecule 1 (KIM-1) and Neutrophil Gelatinase Associated Lipocalin (NGAL) may help clinicians in the clinical evaluation and appropriate planning of the disease. Objective This study aimed to investigate whether serum and urinary KIM-1 and NGAL levels contribute to conventional methods in decision-making for surgery in the postnatal period of infants with antenatal hydronephrosis. Study design 34 patients with the diagnosis of antenatal hydronephrosis were evaluated prospectively. Renal pelvis diameters of all patients were above 10 mm in the ultrasonography (USG). Patients underwent diuretic renal scintigraphy after neonatal period. Patients were divided into two groups as surgery or follow-up based on USG and scintigraphy findings. Blood and urine samples were collected at first visits in both groups and again at the 3. Postoperative month in the surgery group. Serum and urinary NGAL and KIM1 levels were measured by ELISA method. Study data were compared through the Mann-Whitney U and Wilcoxon Signed-Ranks test. Results There were 10 patients in the surgery group and 24 patients in the follow-up group. The age and gender did not differ between the groups. The surgery group had significantly higher median serum NGAL values (259.2 ng/mL) than that in the follow-up group (46.8 ng/mL, p = 0.028). The postoperative reduction of the median serum NGAL to 68.1 ng/mL compared to preoperative level was also found to be significant (p = 0.037) in the surgery group. Between the groups and within the surgery group no statistically significant difference was detected in terms of median urinary NGAL, and serum and urine KIM-1 levels. Discussion USG and renal scintigraphy are frequently used in determining whether patients with antenatal hydronephrosis need surgical intervention in the postnatal period. Several new biomarkers might help clinicians in decision making for surgery. KIM-1 and NGAL levels can be measured both in urine and serum. To our knowledge, this is the only study where serum NGAL and KIM-1 levels were measured in patients with antenatal diagnosis. Small sample size, lack of long term findings and control group are limitations of our study. Conclusion Serum NGAL levels of patients with antenatal hydronephrosis may help in decision making on the surgical intervention.en_US
dc.description.sponsorshipMersin University Scientific Research Project Unit [BAP-TF CTB (DY) 2012-8 TU]en_US
dc.description.sponsorshipThis study was supported by Mersin University Scientific Research Project Unit.Project number: BAP-TF CTB (DY) 2012-8 TU.en_US
dc.identifier.doi10.1016/j.jpurol.2020.10.013
dc.identifier.issn1477-5131
dc.identifier.issn1873-4898
dc.identifier.issue1en_US
dc.identifier.pmid33139211en_US
dc.identifier.scopus2-s2.0-85094979636en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpurol.2020.10.013
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18504
dc.identifier.volume17en_US
dc.identifier.wosWOS:000655529200017en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ltden_US
dc.relation.ispartofJournal Of Pediatric Urologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntenatal Hydronephrosisen_US
dc.subjectKIM-1en_US
dc.subjectNGALen_US
dc.subjectUrinary-Tract Obstructionen_US
dc.subjectUreteropelvic Junction Obstructionen_US
dc.subjectNeonatal Hydronephrosisen_US
dc.subjectChildrenen_US
dc.subjectNgalen_US
dc.subjectBiomarkeren_US
dc.subjectKim-1en_US
dc.subjectDiagnosisen_US
dc.subjectMcp-1en_US
dc.titleCan serum Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 help in decision making for surgery in antenatally dedected hydronephrosisen_US
dc.typeArticleen_US

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