Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model
dc.authorid | adalı, yasemen/0000-0002-8004-7364 | |
dc.authorid | ELMAS, Sait/0000-0003-2607-9987 | |
dc.authorid | Adali, Yasemen/0000-0002-8004-7364 | |
dc.authorid | Kapicibasi, Hasan Oguz/0000-0001-7275-1039 | |
dc.authorid | Demir, Emin Tunc/0000-0002-6945-1091 | |
dc.authorwosid | adalı, yasemen/C-5042-2018 | |
dc.authorwosid | ELMAS, Sait/JUU-6671-2023 | |
dc.authorwosid | Adali, Yasemen/AAE-7859-2021 | |
dc.contributor.author | Kapicibasi, Hasan Oguz | |
dc.contributor.author | Kiraz, Hasan Ali | |
dc.contributor.author | Demir, Emin Tunc | |
dc.contributor.author | Adali, Yasemen | |
dc.contributor.author | Elmas, Sait | |
dc.date.accessioned | 2024-06-12T11:07:55Z | |
dc.date.available | 2024-06-12T11:07:55Z | |
dc.date.issued | 2020 | |
dc.department | Trakya Üniversitesi | en_US |
dc.description.abstract | Purpose: This experimental sepsis model created with Escherichia coil aimed to investigate the histopathological effects of two different doses of ozone combined with antibiotherapy on lung tissue. Methods: Rats were divided into 5 groups. Then sepsis was induced intraperitoneally in the first 4 groups. The 1st group was treated with cefepime, the 2nd and 3rd groups were treated with cefepime combined with ozone at a dose of 0.6 mg/kg and 1.1 mg/kg. Lung tissue sections were stained with hematoxylin-eosin and assessed under light microscope and scored between 0-4 in terms of histopathological findings. Results: In the comparisons between Group 1 and Group 4 in terms of cellular damage (p=0.030), inflammation (p=0.000) and overall score (p=0.007), statistically significant positive effects were observed in favor of Group 1. In the comparisons of Groups 2 and 3 with Group 4, only positive effects were observed in terms of inflammation (p=0.020, p=0.012, respectively). Conclusion: Although negative histopathological effects of ozone on tissue injury were detected, it was noteworthy that the increase in the ozone dose reduced the number of damaged parameters. | en_US |
dc.identifier.doi | 10.1590/s0102-865020200060000004 | |
dc.identifier.issn | 0102-8650 | |
dc.identifier.issn | 1678-2674 | |
dc.identifier.issue | 6 | en_US |
dc.identifier.pmid | 32667585 | en_US |
dc.identifier.scopus | 2-s2.0-85087881549 | en_US |
dc.identifier.scopusquality | Q3 | en_US |
dc.identifier.uri | https://doi.org/10.1590/s0102-865020200060000004 | |
dc.identifier.uri | https://hdl.handle.net/20.500.14551/22236 | |
dc.identifier.volume | 35 | en_US |
dc.identifier.wos | WOS:000550593600001 | en_US |
dc.identifier.wosquality | Q4 | en_US |
dc.indekslendigikaynak | Web of Science | en_US |
dc.indekslendigikaynak | Scopus | en_US |
dc.indekslendigikaynak | PubMed | en_US |
dc.language.iso | en | en_US |
dc.publisher | Acta Cirurgica Brasileira | en_US |
dc.relation.ispartof | Acta Cirurgica Brasileira | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Lung | en_US |
dc.subject | Ozone | en_US |
dc.subject | Sepsis | en_US |
dc.subject | Rats | en_US |
dc.subject | Acute Lung Injury | en_US |
dc.subject | Animal-Model | en_US |
dc.subject | Oxygen | en_US |
dc.subject | Management | en_US |
dc.subject | Mortality | en_US |
dc.title | Pulmonary effects of ozone therapy at different doses combined with antibioticotherapy in experimental sepsis model | en_US |
dc.type | Article | en_US |