Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study

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dc.authoridErdogan, Mumin Alper/0000-0003-0048-444X
dc.authoridTuzcu, Fulya/0000-0002-1528-1090
dc.authoridKhalilnezhad, Asghar/0000-0001-8142-7222
dc.authoridEroğlu, Hüseyin Avni/0000-0002-1040-3255
dc.authoridsolmaz, volkan/0000-0002-9045-2347
dc.authoridErbas, Oytun/0000-0001-5427-8428
dc.authoridTaskiran, Dilek/0000-0002-4505-0939
dc.authorwosidTaskiran, Dilek/AAD-1790-2020
dc.authorwosidErdogan, Mumin Alper/AAR-3140-2021
dc.authorwosidTuzcu, Fulya/AAW-6991-2020
dc.authorwosidKhalilnezhad, Asghar/HGE-9480-2022
dc.authorwosidERBAS, OYTUN/ABA-7380-2021
dc.authorwosidEroğlu, Hüseyin Avni/ABF-4291-2021
dc.contributor.authorErbas, Oytun
dc.contributor.authorErdogan, Mumin Alper
dc.contributor.authorKhalilnezhad, Asghar
dc.contributor.authorSolmaz, Volkan
dc.contributor.authorGurkan, Fulya Tuzcu
dc.contributor.authorYigitturk, Gurkan
dc.contributor.authorEroglu, Huseyin Avni
dc.date.accessioned2024-06-12T10:52:35Z
dc.date.available2024-06-12T10:52:35Z
dc.date.issued2018
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of the present study was to compare the effects of artificial sweeteners (aspartame, saccharin, and sucralose) on rat brain. Twenty-four adult male Sprague-Dawley rats were included in the study. The control group (n = 6) received regular tap water, whereas other groups received aspartame (3mg/kg/day, n = 6,) or saccharin (3mg/kg/day, n = 6) or sucralose (1.5mg/kg/day, n = 6) in the drinkingwater. Following 6weeks, the passive avoidance learning (PAL) test was performed to evaluate the neurobehavioral effects of sweeteners. The brains were assessed for lipid peroxides, neuron count, and Glial fibrillary acidic protein (GFAP) immunohistochemistry. Our results demonstrated that chronic intake of sweeteners significantly impaired PAL performance in all groups. Hippocampal CA1-CA3 areas revealed significantly lower neuronal count in aspartame and increased GFAP expression in all groups. Brain lipid peroxides were significantly higher in all groups. Our findings suggest that long-term consumption of artificial sweeteners may have harmful effects on cognition and hippocampal integrity in rats.en_US
dc.identifier.doi10.1002/jbt.22053
dc.identifier.issn1095-6670
dc.identifier.issn1099-0461
dc.identifier.issue6en_US
dc.identifier.pmid29660801en_US
dc.identifier.scopus2-s2.0-85045399499en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/jbt.22053
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18765
dc.identifier.volume32en_US
dc.identifier.wosWOS:000440795500001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Biochemical And Molecular Toxicologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectArtificial Sweetenersen_US
dc.subjectBrainen_US
dc.subjectOxidative Stressen_US
dc.subjectPassive Avoidance Learningen_US
dc.subjectRaten_US
dc.subjectOxidative Stressen_US
dc.subjectSodium Saccharinen_US
dc.subjectAspartameen_US
dc.subjectMiceen_US
dc.subjectDieten_US
dc.subjectProteinen_US
dc.subjectRisken_US
dc.titleEvaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological studyen_US
dc.typeArticleen_US

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