Mutation detection in the promoter region of survivin gene on N-methyl-N-nitrosourea induced colon tumor model in experiment

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dc.authoridbudak, metin/0000-0002-5968-2048
dc.authorwosidTUNCEL, HANDAN/C-7303-2019
dc.authorwosidBudak, metin/Z-3010-2019
dc.contributor.authorBudak, M.
dc.contributor.authorKorpinar, M. A.
dc.contributor.authorKalkan, T.
dc.contributor.authorTuncel, H.
dc.date.accessioned2024-06-12T11:15:54Z
dc.date.available2024-06-12T11:15:54Z
dc.date.issued2014
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSurvivin (also known as BIRC5) is one of the first reported inhibitors of apoptosis proteins (IAPs), which is an important family of proteins that regulate apoptosis. It is developmentally regulated and expressed during cell differentiation in humans, mice and rat. Survivin is expressed in a series of human cancers and it has been widely accepted that survivin is strongly related to the onset and development of cancer. In the present study, we tried to determine differences in the promoter region of survivin gene in colon tissue samples from N-methyl-N-nitrosourea (MNU) induced rat colon tumor model and control group. Polymerase chain reaction (PCR) single strand conformation polymorphism (SSCP) analysis was used for this aim. No significant differences were found in the promoter region of survivin gene between the normal and tumor tissues (Tab. 2, Fig. 1, Ref. 16). Text in PDF www.elis.sk.en_US
dc.description.sponsorshipIstanbul University Research Fund [BYP-415/060504]en_US
dc.description.sponsorshipThis study was funded by Istanbul University Research Fund (Project No: BYP-415/060504).en_US
dc.identifier.doi10.4149/BLL_2014_107
dc.identifier.endpage556en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue9en_US
dc.identifier.pmid25318914en_US
dc.identifier.scopus2-s2.0-84908179618en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage554en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_107
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24110
dc.identifier.volume115en_US
dc.identifier.wosWOS:000343078300006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSurvivinen_US
dc.subjectPromoteren_US
dc.subjectSingle Strand Conformational Polymorphism (SSCP)en_US
dc.subjectRaten_US
dc.subjectExpressionen_US
dc.subjectApoptosisen_US
dc.subjectCanceren_US
dc.subjectPolymorphismen_US
dc.subjectRatsen_US
dc.titleMutation detection in the promoter region of survivin gene on N-methyl-N-nitrosourea induced colon tumor model in experimenten_US
dc.typeArticleen_US

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