Mean platelet volume in patients with nonvalvular atrial fibrillation

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dc.authorwosidTekin, Yusuf Kenan/AAH-7137-2019
dc.contributor.authorTekin, Gulacan
dc.contributor.authorTekin, Yusuf Kenan
dc.contributor.authorSivri, Nasir
dc.contributor.authorYetkin, Ertan
dc.date.accessioned2024-06-12T10:52:49Z
dc.date.available2024-06-12T10:52:49Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe procoagulant and prothrombotic states in patients with chronic atrial fibrillation are higher than those in patients with normal sinus rhythm. Mean platelet volume (MPV) which is a marker of platelet function and activation can reflect changes either in the level of platelet stimulation or the rate of platelet production. In this study, we aimed to assess and compare the hematologic parameters of routine complete blood count analysis in elderly patients with nonvalvular atrial fibrillation and control individuals with normal sinus rhythm. One hundred and seven consecutive patients with nonvalvular chronic atrial fibrillation and 112 age and sex-matched control individuals with normal sinus rhythm were retrospectively included in the study from the outpatient cardiology clinic. Hematological variables, including MPV, platelet count, red blood cell and white blood cell count were measured in all patients and control individuals. Presence of coronary artery disease, hypertension, sex, hyperlipidemia, diabetes mellitus, smoking status, hematocrit and platelet count were comparable between two groups (P>0.05 for all). However, MPV and white blood cell count were significantly higher in patients with atrial fibrillation compared to those without atrial fibrillation. Logistic regression analysis revealed that white blood cell count and MPV significantly and independently associated with atrial fibrillation. We have shown that MPV and white blood cell count is independently associated with chronic nonvalvular atrial fibrillation. To improve the clinical utility of MPV and role of inflammation in the pathogenesis of atrial fibrillation, further studies are needed to be carried out. (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.en_US
dc.identifier.doi10.1097/MBC.0b013e32835facb3
dc.identifier.endpage539en_US
dc.identifier.issn0957-5235
dc.identifier.issn1473-5733
dc.identifier.issue5en_US
dc.identifier.pmid23571683en_US
dc.identifier.scopus2-s2.0-84879945079en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage537en_US
dc.identifier.urihttps://doi.org/10.1097/MBC.0b013e32835facb3
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18846
dc.identifier.volume24en_US
dc.identifier.wosWOS:000326588900013en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofBlood Coagulation & Fibrinolysisen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAtrial Fibrillationen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectPlatelet Activationen_US
dc.subjectWhite Blood Cellen_US
dc.subjectCoronary-Artery Diseaseen_US
dc.subjectIndependent Risk Factoren_US
dc.subjectBeta-Thromboglobulinen_US
dc.subjectMitral-Stenosisen_US
dc.subjectP-Selectinen_US
dc.subjectActivationen_US
dc.subjectStrokeen_US
dc.subjectStateen_US
dc.titleMean platelet volume in patients with nonvalvular atrial fibrillationen_US
dc.typeArticleen_US

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