CUTANEOUS INFECTION CAUSED BY ALTERNARIA ALTERNATA IN AN IMMUNOCOMPETENT HOST

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dc.authoridKılıç, Haluk/0000-0002-3222-0601
dc.authoridPiskin, Senol/0000-0002-8799-9472
dc.authoridGurcan, Saban/0000-0002-5052-481X
dc.authorwosidKılıç, Haluk/C-6625-2017
dc.authorwosidPişkin, Süleyman/ABC-2562-2020
dc.authorwosidPiskin, Senol/F-3741-2019
dc.authorwosidGurcan, Saban/D-2754-2017
dc.contributor.authorGuercan, Saban
dc.contributor.authorPiskin, Sueleyman
dc.contributor.authorKilic, Haluk
dc.contributor.authorTemelli, Baksel Ay
dc.contributor.authorYalcin, Oemer
dc.date.accessioned2024-06-12T10:51:20Z
dc.date.available2024-06-12T10:51:20Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractHuman infections caused by Alternaria alternata are more frequently reported in immunosupressive hosts. In this report, a rarely seen cutaneous infection, caused by A.alternata in an immunocompetent patient was presented. The patient (71 years-old, male) was admitted to the dermatology unit with complaints of an erythematous and squamatous lesion of 5 cm diameter on left malleolar region. The case was evaluated as immunocompetent based on the normal serum total immunoglobulin and complement levels, anti-HIV negativity, and no known underlying disease. A number of Alternaria spp. conidia and hypha were seen in the microscopical examination of KOH treated cutaneous scrapings of the lesion obtained in two different days. Fungal cultures of the skin scrapings yielded the growth of a fungus identified as A.alternata. Although fungal elements were not detected in haematoxylene-eosin stained smears of the skin biopsy, A.alternato was again isolated in the culture of the biopsy specimen. The identification of the fungus was confirmed by a reference center (Mycology Section of Scientific Institute of Public Health, Belgium) and it was integrated to BCCM/IHEM collection under accession number IHEM 22598. Antifungal susceptibility test efforts failed due to a problem in the preparation of fungal suspension. Oral itraconazole (200 mg/day) and bifonazole cream was used for the treatment and the lesion regressed after the 19(th) day of the therapy. The treatment was continued with oral and local terbinafine for two weeks and the patient fully recovered. Since A.alternata was demonstrated both in the skin scrapings and tissue biopsy through microscopic examination and culture, it was evaluated as the causative agent of skin infection rather than colonization. This was the first A.alternato infection in an immunocompetent patient in the light of the current literature.en_US
dc.identifier.endpage167en_US
dc.identifier.issn0374-9096
dc.identifier.issue1en_US
dc.identifier.pmid19334395en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18322
dc.identifier.volume43en_US
dc.identifier.wosWOS:000263117000022en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isotren_US
dc.publisherAnkara Microbiology Socen_US
dc.relation.ispartofMikrobiyoloji Bultenien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAlternaria Alternataen_US
dc.subjectCutaneous Infectionen_US
dc.subjectImmunocompetent Hosten_US
dc.titleCUTANEOUS INFECTION CAUSED BY ALTERNARIA ALTERNATA IN AN IMMUNOCOMPETENT HOSTen_US
dc.typeArticleen_US

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