Protective effect of the N-methyl-D-aspartate receptor antagonists, MK-801 and CPP on cold-induced brain oedema

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dc.authoridKiris, Talat/0000-0002-2985-3758
dc.authorwosidKiris, Talat/AAP-4665-2020
dc.contributor.authorGörgülü, A
dc.contributor.authorKiris, T
dc.contributor.authorÜnal, F
dc.contributor.authorTürkoglu, Ü
dc.contributor.authorKüçük, M
dc.contributor.authorÇobanoglu, S
dc.date.accessioned2024-06-12T10:58:04Z
dc.date.available2024-06-12T10:58:04Z
dc.date.issued1999
dc.departmentTrakya Üniversitesien_US
dc.description.abstractCold injury model in rat was used to determine the effect of treatment with the competitive NMDA antagonists CPP and the noncompetitive NMDA antagonist MK-801 in cerebral oedema. MK-801 was applied in doses of 1 mg/kg and CPP of 10 mg/kg, 15 min. after injury. Control animals received 1 mi saline at the same time interval after injury. Tissue samples from the core and periphery of the lesion of the injured hemisphere and from the symmetrical location of the undamaged contralateral hemisphere were removed 24 hours after injury. Blood brain barrier permeability, brain water content and tissue specific gravity values were determined. MK-801 was found beneficial for reducing the oedema and restore the blood brain barrier permeability at the penumbral zone of the lesion, whereas both MK-801 and CPP were found ineffective for prevention of oedema accumulation at the core of the lesion.en_US
dc.identifier.doi10.1007/s007010050271
dc.identifier.endpage98en_US
dc.identifier.issn0001-6268
dc.identifier.issn0942-0940
dc.identifier.issue1en_US
dc.identifier.pmid10071692en_US
dc.identifier.scopus2-s2.0-0032950605en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage93en_US
dc.identifier.urihttps://doi.org/10.1007/s007010050271
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19922
dc.identifier.volume141en_US
dc.identifier.wosWOS:000078554900031en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Wienen_US
dc.relation.ispartofActa Neurochirurgicaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCold Injuryen_US
dc.subjectBrain Oedemaen_US
dc.subjectNMDA Receptor Antagonistsen_US
dc.subjectFocal Cerebral-Ischemiaen_US
dc.subjectSpinal-Cord Injuryen_US
dc.subjectExcitatory Amino-Acidsen_US
dc.subjectFree Fatty-Acidsen_US
dc.subjectRat-Brainen_US
dc.subjectNeuronal Damageen_US
dc.subjectGlutamate Antagonisten_US
dc.subjectCerebrospinal-Fluiden_US
dc.subjectEdemaen_US
dc.subjectReleaseen_US
dc.titleProtective effect of the N-methyl-D-aspartate receptor antagonists, MK-801 and CPP on cold-induced brain oedemaen_US
dc.typeArticleen_US

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