A New Combination Therapy in Severe Acute Pancreatitis-Hyperbaric Oxygen Plus 3-Aminobenzamide An Experimental Study

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dc.authoridinal, volkan/0000-0003-2649-104X
dc.authoridCömert, Bilgin/0000-0002-2148-5356
dc.authoridTASCI, ILKER/0000-0002-0936-2476
dc.authoridDeveci, Mehmet Salih/0000-0001-9612-5198
dc.authoridISIK, Ahmet Turan/0000-0001-5867-6503
dc.authorwosidinal, volkan/A-6069-2018
dc.authorwosidCömert, Bilgin/P-3030-2019
dc.authorwosidTASCI, ILKER/B-7556-2009
dc.authorwosidAYDIN, SEZAİ/JXX-4162-2024
dc.authorwosidDeveci, Mehmet Salih/AAA-1343-2020
dc.contributor.authorInal, Volkan
dc.contributor.authorMas, Mehmet Refik
dc.contributor.authorIsik, Ahmet Turan
dc.contributor.authorComert, Bilgin
dc.contributor.authorAydin, Sezai
dc.contributor.authorMas, Nukhet
dc.contributor.authorDeveci, Mehmet Salih
dc.date.accessioned2024-06-12T11:01:37Z
dc.date.available2024-06-12T11:01:37Z
dc.date.issued2015
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjectives: This study was designed to evaluate effects of hyperbaric oxygen (HBO) plus 3-aminobenzamide (3-AB) cotreatment on tissue oxidative stress parameters (TOSp), tissue histopathology scores (THSc), and bacterial translocations (Bact-Trans) in an experimental model of severe acute pancreatitis (AP). Methods: Seventy-five Sprague-Dawley rats were randomized into 5 groups. Group 1 received sham. Severe AP was induced by intraductal taurocholate infusion and then group 2 received saline, group 3 received 3-AB, group 4 received 3-AB plus HBO, and group 5 received HBO. 3-Aminobenzamide (10 mg/kg per day, once daily, intraperitoneal) and saline (1 mL/kg) were started right after the induction, whereas HBO (2,8 atm pressure, BID, 90 minutes each) was started at the sixth hour. The rats were euthanized at the 54th hour, and TOSp, THSc, and Bact-Trans were studied. Results: In treatment groups 3 and 5, Bact-Trans (P < 0.05, P < 0.05), TOSp (P < 0.05, P < 0.05), and THSc (P < 0.001, P < 0.001) were significantly lower than controls. In addition to these findings, group 4 (cotreatment) showed the most significant effect on Bact-Trans and THSc (P < 0.001, P < 0.001) and also better in TOSp (P < 0.02). Conclusions: Poly(ADP-ribose) polymerase inhibition by 3-AB and HBO treatment alone was effective in the course of severe AP, and favorable with cotreatment because of the improved cascades of inflammatory process by different aspects.en_US
dc.identifier.doi10.1097/MPA.0000000000000240
dc.identifier.endpage330en_US
dc.identifier.issn0885-3177
dc.identifier.issn1536-4828
dc.identifier.issue2en_US
dc.identifier.pmid25347462en_US
dc.identifier.scopus2-s2.0-84925879084en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage326en_US
dc.identifier.urihttps://doi.org/10.1097/MPA.0000000000000240
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20968
dc.identifier.volume44en_US
dc.identifier.wosWOS:000349769400022en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofPancreasen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExperimental Pancreatitisen_US
dc.subject3-Aminobenzamideen_US
dc.subjectHyperbaric Oxygenen_US
dc.subjectOxidative Stressen_US
dc.subjectBacterial Translocationen_US
dc.subjectAcute Pancreatitisen_US
dc.subjectAcute Necrotizing Pancreatitisen_US
dc.subjectPoly(Adp-Ribose) Polymerase Inhibitorsen_US
dc.subjectBacterial Translocationen_US
dc.subjectOxidative Stressen_US
dc.subjectRatsen_US
dc.subjectManagementen_US
dc.subjectApoptosisen_US
dc.subjectCeruleinen_US
dc.subjectNecrosisen_US
dc.subjectPlasmaen_US
dc.titleA New Combination Therapy in Severe Acute Pancreatitis-Hyperbaric Oxygen Plus 3-Aminobenzamide An Experimental Studyen_US
dc.typeArticleen_US

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