Effect of formaldehyde inhalation on rat livers: A light and electron microscopic study

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dc.contributor.authorCikmaz, Selman
dc.contributor.authorKutoglu, Tunc
dc.contributor.authorKanter, Mehmet
dc.contributor.authorMesut, Recep
dc.date.accessioned2024-06-12T11:02:09Z
dc.date.available2024-06-12T11:02:09Z
dc.date.issued2010
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIt is well known that formaldehyde (FA) is cytotoxic and potentially carcinogenic. Although the individual effects of this reactant on cells has been investigated, the cytotoxicity exerted by the coexistence of FA is poorly understood. The aim of this study was to investigate the effects of FA on the liver in rats, by light and electron microscopic level. We used 18 Wistar albino rats divided into three groups, exposed to 0 (control), 19.7 ppm FA gas for a total of 4 weeks, 8 h/day, 5 days a week (subacute) and 20.3 parts per million (ppm) FA gas for a total of 13 weeks, 8 h/day, 5 days a week (subchronic). After the completion of the exposure period, they were sacrificed by decapitation and their liver tissue samples were taken in order to be processed for light and electron microscopic studies. Light microscopic evaluation of liver tissue samples of FA-exposed rats revealed enlarged sinusoids filled with blood and mononuclear cell infiltration in the portal areas and around the central veins. In addition, some of the hepatocytes showed loss of cytoplasm, and some had a hyperchromatic nucleus. The cells of FA-exposed livers, on the other hand, showed an electron-lucent ground-cytoplasm and a hypertrophy of the smooth-surfaced endoplasmic reticulum. In conclusion, we observed that exposure FA caused diverse histopathological changes indicating the destruction in the liver tissue and this destruction has direct relationship with the length of the exposure period.en_US
dc.identifier.doi10.1177/0748233710362384
dc.identifier.endpage119en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue2en_US
dc.identifier.pmid20207655en_US
dc.identifier.scopus2-s2.0-77951931536en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage113en_US
dc.identifier.urihttps://doi.org/10.1177/0748233710362384
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21173
dc.identifier.volume26en_US
dc.identifier.wosWOS:000275230700005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofToxicology And Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFormaldehydeen_US
dc.subjectLiveren_US
dc.subjectLight Microscopeen_US
dc.subjectElectron Microscopeen_US
dc.subjectRaten_US
dc.subjectCell-Proliferationen_US
dc.subjectNasal Cavityen_US
dc.subjectExposureen_US
dc.subjectHepatotoxicityen_US
dc.subjectToxicologyen_US
dc.subjectInductionen_US
dc.subjectToxicityen_US
dc.subjectMiceen_US
dc.titleEffect of formaldehyde inhalation on rat livers: A light and electron microscopic studyen_US
dc.typeArticleen_US

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