Revisiting Weight-Normalized SUV and Lean-Body-Mass-Normalized SUV in PET Studies

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dc.authoridSarikaya, Ismet/0000-0002-1087-580X
dc.authoridAlbatineh, Ahmed Najeeb/0000-0001-5646-4945
dc.authorwosidSarikaya, Ismet/G-7881-2015
dc.contributor.authorSarikaya, Ismet
dc.contributor.authorAlbatineh, Ahmed N.
dc.contributor.authorSarikaya, Ali
dc.date.accessioned2024-06-12T11:15:55Z
dc.date.available2024-06-12T11:15:55Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSUV normalized by total body weight is affected by the amount of body fat. The SUV of normal tissues and lesions is higher (overestimated) in obese patients than in patients with a normal body mass index (BMI). SUL (SUV normalized by lean body mass [LBM]) is recommended for more accurate SUV results. Given the importance of a quantitative PET parameter, particularly when comparing PET studies, we aimed to revisit the effect of obesity on SUV, measuring SUL in normal-BMI patients and obese patients and testing the effect of the amount of LBM. Methods: F-18-FDG whole- body images of adult patients were analyzed retrospectively. We measured both SUVmax and SUVmean in the blood pool and liver of patients with a normal BMI (18.5-24.9) and a high BMI (>= 30) (obese). In all patients, we calculated LBM via an equation using patient height and weight and corrected all SUVs to SULs. Mean (+/- SD) SUVs and SULs were compared under various circumstances. Scatterplots were generated for weight and SUV-SUL differences. Results: SUVmean in the liver and blood pool was significantly higher in obese patients (30 patients) than in patients with a normal BMI (20 patients) (4.1 +/- 0.7 and 3.0 +/- 0.5, respectively, in liver, vs. 3.2 +/- 0.6 and 2.4 +/- 0.4, respectively, in blood pool; P < 0.001). SULmean was significantly lower in both liver and blood pool in all patients, being approximately 75% of SUVmean in patients with a normal BMI and 55% of SUVmean in obese patients (P < 0.001). SULmean in the liver and blood pool did not significantly differ between obese patients and normalBMI patients (P > 0.05). The SUV-SUL difference was significantly higher in obese patients than in patients with a normal BMI (P < 0.001). These statistical results were the same when SUVmax and SULmax were compared. Conclusion: SUV overestimates metabolic activity in all patients, and this overestimation is more significant in obese patients than in patients with a normal BMI. SUL is not affected by body weight or the amount of LBM.en_US
dc.identifier.doi10.2967/jnmt.119.233353
dc.identifier.endpage167en_US
dc.identifier.issn0091-4916
dc.identifier.issn1535-5675
dc.identifier.issue2en_US
dc.identifier.pmid31604893en_US
dc.identifier.scopus2-s2.0-85086481336en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage163en_US
dc.identifier.urihttps://doi.org/10.2967/jnmt.119.233353
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24114
dc.identifier.volume48en_US
dc.identifier.wosWOS:000539259000017en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Nuclear Medicine Incen_US
dc.relation.ispartofJournal Of Nuclear Medicine Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectSUVen_US
dc.subjectSULen_US
dc.subjectLean Body Massen_US
dc.subjectWeighten_US
dc.subjectPETen_US
dc.subjectStandardized Uptake Valuesen_US
dc.subjectPediatric-Patientsen_US
dc.subjectFdg Uptakeen_US
dc.subjectCanceren_US
dc.titleRevisiting Weight-Normalized SUV and Lean-Body-Mass-Normalized SUV in PET Studiesen_US
dc.typeArticleen_US

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