Copeptin and cardiovascular disease: A review of a novel neurohormone

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dc.contributor.authorYalta, Kenan
dc.contributor.authorYalta, Tulin
dc.contributor.authorSivri, Nasir
dc.contributor.authorYetkin, Ertan
dc.date.accessioned2024-06-12T10:58:29Z
dc.date.available2024-06-12T10:58:29Z
dc.date.issued2013
dc.departmentTrakya Üniversitesien_US
dc.description.abstractNeurohormones (NHs) in the cascade of the arginine vasopressin (AVP) system have drawn particular attention in the recent years. Copeptin, the C-terminal portion of provasopressin, is a novel NH of the AVP system, and is known to be co-released with AVP from hypothalamus (neurohypophysis). As a surrogate marker of the AVP system, copeptin has gradually replaced AVP in several clinical studies largely due to its structural and methodological advantages. Copeptin has been regarded as a marker of non-specific stress response, and has also been suggested to have clinical implications in a variety of non-cardiovascular (pneumonia, sepsis, etc.) and cardiovascular conditions (heart failure and acute coronary syndromes (ACSs, etc.)). However, current data on relation of copeptin with other cardiovascular conditions (arrhythmias, etc.) are still insufficient. The present review primarily focuses on general features of copeptin, its general clinical implications, and specifically aims to cover its potential clinical value in a variety of cardiovascular conditions. (C) 2012 Elsevier Ireland Ltd. All rights reserved.en_US
dc.identifier.doi10.1016/j.ijcard.2012.12.039
dc.identifier.endpage1759en_US
dc.identifier.issn0167-5273
dc.identifier.issn1874-1754
dc.identifier.issue5en_US
dc.identifier.pmid23298558en_US
dc.identifier.scopus2-s2.0-84883303780en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1750en_US
dc.identifier.urihttps://doi.org/10.1016/j.ijcard.2012.12.039
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20085
dc.identifier.volume167en_US
dc.identifier.wosWOS:000323569600028en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofInternational Journal Of Cardiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCopeptinen_US
dc.subjectArginine Vasopressinen_US
dc.subjectCardiovascular Diseaseen_US
dc.subjectClinical Implicationen_US
dc.subjectTerminal Provasopressin Copeptinen_US
dc.subjectAcute Myocardial-Infarctionen_US
dc.subjectChronic Heart-Failureen_US
dc.subjectArginine-Vasopressin Increasesen_US
dc.subjectGerman Competence Networken_US
dc.subjectHigh-Sensitivity Troponinen_US
dc.subjectC-Reactive Proteinen_US
dc.subjectNatriuretic Peptideen_US
dc.subjectRisk Stratificationen_US
dc.subjectPrognostic Markeren_US
dc.titleCopeptin and cardiovascular disease: A review of a novel neurohormoneen_US
dc.typeReview Articleen_US

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