Alterations of BDNF and GDNF serum levels in alcohol-addicted patients during alcohol withdrawal

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dc.authoridvardar, mehmet erdal/0000-0002-5836-6174
dc.authoridGorgulu, Yasemin/0000-0002-3401-4879
dc.authorid, Rugül/0000-0003-2596-0473;
dc.authorwosidvardar, mehmet erdal/ABI-5764-2020
dc.authorwosidGorgulu, Yasemin/S-4355-2017
dc.authorwosidvardar, mehmet erdal/AAB-7287-2021
dc.authorwosid, Rugül/AAI-1711-2019
dc.authorwosidçınar, rugül köse/S-8927-2019
dc.contributor.authorSonmez, Mehmet Bulent
dc.contributor.authorGorgulu, Yasemin
dc.contributor.authorCinar, Rugul Kose
dc.contributor.authorKilic, Evnur Kahyaci
dc.contributor.authorUnal, Aycan
dc.contributor.authorVardar, Mehmet Erdal
dc.date.accessioned2024-06-12T10:54:15Z
dc.date.available2024-06-12T10:54:15Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground and Objectives: Brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) are neurotrophic neuropeptides that play important roles in the synaptic plasticity, neuronal growth, survival and function. A possible neuroprotective role of neurotrophic factors against alcohol-induced cell damage has been suggested, and dysregulations in neurotrophic factors may be involved in the vulnerability to addiction. The aim of this study was to investigate the alterations of BDNF and GDNF serum levels in alcohol-addicted patients during alcohol withdrawal compared to healthy controls. Methods: BDNF and GDNF serum levels of 34 male inpatients diagnosed with alcohol addiction according to DSM-IV-TR were investigated during alcohol withdrawal (day 1, 7 and 14) in comparison to 32 healthy controls using an enzyme-linked immunosorbent assay (ELISA). Severity of alcohol withdrawal was measured by Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar), and intensity of alcohol craving was measured by Penn Alcohol Craving Scale (PACS) during alcohol withdrawal (day 1, 7 and 14). Results: BDNF serum levels increased significantly during alcohol withdrawal (p = 0.020). They were negatively correlated to the severity of alcohol withdrawal, and the correlation was close to being statistically significant (p = 0.058). BDNF and GDNF serum levels did not differ significantly between the patient and control groups. GDNF serum levels did not change significantly during alcohol withdrawal. Conclusions: Our results may provide support for the previously hypothesized role of BDNF in the neuroadaptation during alcohol withdrawal.en_US
dc.description.sponsorshipScientific Research Projects Unit of the Trakya University, Edirne, Turkey [2013-90]en_US
dc.description.sponsorshipThis study was supported by grant form the Scientific Research Projects Unit of the Trakya University, Edirne, Turkey (Project No: 2013-90). The authors thank Prof Hakan Erba from the Department of Medical Biochemistry (Trakya University, School of Medicine, Edirne, Turkey) for laboratory assistance.en_US
dc.identifier.endpage118en_US
dc.identifier.issn0213-6163
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84994639500en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18983
dc.identifier.volume30en_US
dc.identifier.wosWOS:000386549500002en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherEuropean Journal Of Psychiatryen_US
dc.relation.ispartofEuropean Journal Of Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBDNFen_US
dc.subjectGDNFen_US
dc.subjectAlcoholen_US
dc.subjectAddictionen_US
dc.subjectWithdrawalen_US
dc.subjectNeurotrophic Factor Levelsen_US
dc.subjectUse Disordersen_US
dc.subjectBrainen_US
dc.subjectConsumptionen_US
dc.subjectRelapseen_US
dc.subjectRewarden_US
dc.subjectScaleen_US
dc.titleAlterations of BDNF and GDNF serum levels in alcohol-addicted patients during alcohol withdrawalen_US
dc.typeArticleen_US

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