Synthesis of some piperazinobenzoxazole derivatives and their antimicrobial properties

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dc.authoridARISOY, MUSTAFA/0000-0002-8260-3918
dc.authoridtemiz arpaci, ozlem/0000-0001-6221-5347
dc.authorwosidarpaci, ozlem temiz/AAH-1281-2020
dc.authorwosidARISOY, MUSTAFA/AAZ-6067-2021
dc.authorwosidONURDAG, Fatma KAYNAK/T-2518-2017
dc.contributor.authorArisoy, Mustafa
dc.contributor.authorTemiz-Arpaci, Ozlem
dc.contributor.authorKaynak-Onurdag, Fatma
dc.contributor.authorOzgen, Selda
dc.date.accessioned2024-06-12T10:54:24Z
dc.date.available2024-06-12T10:54:24Z
dc.date.issued2016
dc.departmentTrakya Üniversitesien_US
dc.description.abstractA series of 2-(p-substitutedphenynenzy1)-5-[3-[4-[(p-chlorophenyl)/phenyl]piperazin-1-yl]propionamido]-benzoxazoles (3-22) have been synthesized towards discovering new antimicrobial compounds in order to fight against pathogens, which have become resistant to antibiotics and are the cause of increased mortality and morbidity throughout the world. Structures of new derivatives have been elucidated by spectral techniques. New and previously synthesized benzoxazoles have been evaluated for their antibacterial and antifungal activity against standard strains, and their drug-resistant isolates in comparison with reference drugs. This study is aimed to investigate the efficacy of the antimicrobial effect of different amido bridges on the same homologue structures of benzoxazole compounds. Compounds 3-22 exhibit broad antibacterial activity with MIC (Minimum Inhibitory Concentration) values of 128-256 mu g/mL against Staphylococcus aureus and its isolate except for derivative 7 that has a MIC value of 32 mu g/mL against S. aureus isolate and compounds 3 and 22 which have MIC value of 512 mu g/mL against S. aureus. Also, the tested compounds 3-22 possess low antifungal activity with MIC values of 128 mu g/mL against Candida albicans in comparison with antifungal reference drugs, fluconazole and amphotericin B.en_US
dc.description.sponsorshipAnkara University Research Fund [12L 3336001]; Central Laboratory of the Faculty of Pharmacy of Ankara Universityen_US
dc.description.sponsorshipThis work was supported by Ankara University Research Fund (Grant No 12L 3336001). The Central Laboratory of the Faculty of Pharmacy of Ankara University supported the acquisition of the NMR and mass spectra and elemental analyses in this work.en_US
dc.identifier.endpage247en_US
dc.identifier.issn0376-4699
dc.identifier.issn0019-5103
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85009289285en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage240en_US
dc.identifier.urihttps://hdl.handle.net/20.500.14551/19038
dc.identifier.volume55en_US
dc.identifier.wosWOS:000370677800006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherCouncil Scientific & Industrial Resen_US
dc.relation.ispartofIndian Journal Of Chemistry Section B-Organic Chemistry Including Medicinal Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzoxazoleen_US
dc.subjectPropionamideen_US
dc.subjectAntifungal Activityen_US
dc.subjectAntibacterial Activityen_US
dc.subjectPiperazineen_US
dc.subjectBacterial 2-Component Systemsen_US
dc.subjectBenzoxazolesen_US
dc.subjectAntibacterialen_US
dc.subjectInhibitorsen_US
dc.subjectAnalogsen_US
dc.subjectBenzimidazoleen_US
dc.subjectAntifungalen_US
dc.subjectLyaseen_US
dc.titleSynthesis of some piperazinobenzoxazole derivatives and their antimicrobial propertiesen_US
dc.typeArticleen_US

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