Kolorektal kanserli olgularda oksidatif stresin araştırılması
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Dosyalar
Tarih
2010
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Trakya Üniversitesi Tıp Fakültesi
Trakya Üniversitesi Tıp Fakültesi
Trakya Üniversitesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Kolorektal kanser; yaşam kalitesini düşüren, iş-güç kaybına yol açan önemli bir sağlık sorunu olarak günümüzde en sık görülen kanserlerdendir. Birçok kanser tipinde olduğu gibi kolorektal kanser oluşumu ve gelişiminde de oksidatif hasar ve inflamasyonun etkisi olduğu düşünülmektedir. Çalışmamızın amacı kolorektal kanserde oksidatif ve nitrozatif stresi incelemek, lökosit aktivasyonu ile ilişkisini ortaya koymaktır. Çalışma gruplarımızı kolorektal kanser tanısı alan hastalar (n=21) ile kontrol grubu olarak sağlıklı kişiler (n=21) oluşturdu. Kolorektal kanser ile kontrol grupları arasında yaş ortalaması ve cinsiyet dağılımı bakımından anlamlı bir fark saptanmadı. Kolorektal kanserli hasta grubunda serum malondialdehid ve plazma miyeloperoksidaz düzeyleri kontrol grubuna göre artmış olarak bulundu (sırasıyla; p<0.05 ve p<0.01). Plazma nitrotirozin ve nitrik oksit düzeyleri kolorektal kanser grubunda kontrol grubuna göre artmıştı (ikisi de; p<0.01 ve p<0.01). Olguların tümü ele alındığında plazma nitrik oksit ve nitrotirozin düzeyleri arasında pozitif bir ilişki (r = 0.504, p<0.001) olduğu, diğer parametreler arasında ise korelasyon olmadığı görüldü. Gruplar ayrı ayrı incelendiğinde kontrol grubundaki parametreler arasında herhangi bir ilişki bulunmazken; kolorektal kanserli olguların plazma nitrik oksit düzeyleri ile plazma nitrotirozin düzeyleri arasında pozitif ilişki (r = 0.569, p<0.01) olduğu görüldü. Son olarak; bu bulgular kolorektal kansinomda oksidatif ve nitrozatif stresin olduğuna işaret etmektedir. Ayrıca, nitrozatif stresin plazma proteinlerinin oksidasyonuna yol açabileceğini söyleyebiliriz.
Abstract
Colorectal cancer is one of the most endemic cancers as a significant health problem that decrease the life quality and cause job loss. As in several cancer types, it is also thought that oxidative damage and its inflammation have an effect on colorectal cancer composition and development. Aim of our study is to examine oxidative stress and nitrosative stress at colorectal cancer, introduce its correlation with leucocyte activation. Our study groups composed of patients with colorectal cancer diagnosis (n=21) and healthy people as control group (n=21). A significantly difference has not been determined in terms of age average and gender dispersion between the colorectal cancer and the control groups. Serum malondialdehyde and plasma myeloperoxidase levels of the colorectal cancer group were higher than those of the control group (respectively; p<0.05 and p<0.01). The levels of plasma nitrotyrosine and nitric oxide were increased in the colorectal cancer group compared as to the control group (both; p<0.01). Considering all the cases together, it has been seen that there was a positive correlation between plasma nitrotyrosine and nitric oxide levels (r = 0.504, p<0.01), but any correlations were not observed among other parameters. When the groups analyzed separately, any correlation has not been determined among parameters of the control group; however, a positive correlation has been seen that between plasma nitric oxide and plasma nitrotyrosine levels of the colorectal cancer group (r = 0.504, p<0.01). In conclusion, these findings indicate that there were an oxidative and nitrosative stress in the colorectal carcinoma. Also, we say that nitrosative stres may caused to oxidation of the plasma proteins.
Abstract
Colorectal cancer is one of the most endemic cancers as a significant health problem that decrease the life quality and cause job loss. As in several cancer types, it is also thought that oxidative damage and its inflammation have an effect on colorectal cancer composition and development. Aim of our study is to examine oxidative stress and nitrosative stress at colorectal cancer, introduce its correlation with leucocyte activation. Our study groups composed of patients with colorectal cancer diagnosis (n=21) and healthy people as control group (n=21). A significantly difference has not been determined in terms of age average and gender dispersion between the colorectal cancer and the control groups. Serum malondialdehyde and plasma myeloperoxidase levels of the colorectal cancer group were higher than those of the control group (respectively; p<0.05 and p<0.01). The levels of plasma nitrotyrosine and nitric oxide were increased in the colorectal cancer group compared as to the control group (both; p<0.01). Considering all the cases together, it has been seen that there was a positive correlation between plasma nitrotyrosine and nitric oxide levels (r = 0.504, p<0.01), but any correlations were not observed among other parameters. When the groups analyzed separately, any correlation has not been determined among parameters of the control group; however, a positive correlation has been seen that between plasma nitric oxide and plasma nitrotyrosine levels of the colorectal cancer group (r = 0.504, p<0.01). In conclusion, these findings indicate that there were an oxidative and nitrosative stress in the colorectal carcinoma. Also, we say that nitrosative stres may caused to oxidation of the plasma proteins.
Açıklama
Tıpta Uzmanlık Tezi
Anahtar Kelimeler
Kolorektal Kanser, Malondialdehid, Miyeloperoksidaz, Nitrotirozin, Nitrik Oksit, Colorectal Cancer, Malondialdehyde, Myeloperoxidase, Nitrotyrosine, Nitric Oxide
