Clearance of technetium-99m-labeled DTPA in hyperthyroidism without clinical evidence of lung disease, and relation to pulmonary function

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dc.authoridDURMUS ALTUN, GULAY/0000-0002-1822-9386
dc.authorwosidDURMUS ALTUN, GULAY/S-6586-2016
dc.contributor.authorGuldiken, S
dc.contributor.authorTugrul, A
dc.contributor.authorAltiay, G
dc.contributor.authorHacimahmutoglu, S
dc.contributor.authorDurmus-Altun, G
dc.date.accessioned2024-06-12T11:03:36Z
dc.date.available2024-06-12T11:03:36Z
dc.date.issued2005
dc.departmentTrakya Üniversitesien_US
dc.description.abstractObjective: The mechanisms of dyspnea and exercise intolerance have not been fully elucidated. We aimed to investigate the clearance rate of technetium-99m diethyltriaminepentaaceticacid (Tc-99m DTPA) from lungs in hyperthyroid patients without clinical evidence of lung disease and to explore the interactions between their Tc-99m DTPA radioaerosol lung scintigraphy, spirometric measurements, and the levels of thyroid hormones. Methods: We studied 19 hyperthyroid patients and 16 sex- and age-matched controls. Thyroid hormone levels were assessed. Spirometric lung function tests, diffusing capacity of the lung for carbon monoxide (DLCO) and the clearance rate of Tc-99m DTPA were performed in all participants. Ratio of DLCO value to the alveolar ventilation (DLCO/VA) and the means of half-time (T-1/2) of Tc-99m DTPA clearance rate, which were used to evaluate alveolar-capillary membrane permeability, were calculated. Results: There were no statistical differences between spirometfic parameters (VC, FVC, FEV1/FVC, FEF 25-75) of the two groups (p > 0.05). Although the mean FEV1 level was significantly lower in the hyperthyroid patients than the control subjects (p < 0.01), in five patients FEV1 was only less than 80 percent of the predicted value. No significant difference in the means of DLCO, DLCO/VA or T-1/2 values of Tc-99m DTPA clearance was observed between the two groups (p > 0.05). In hyperthyroid patients, there was a positive relation between DLCO/VA, DLCO/VA % and T-1/2 values of Tc-99m DTPA clearance (p < 0.01, r = 0.732, p < 0.01, r = 0.742, respectively). The lung volumes and the levels of thyroid hormones did not show a significant relationship to T-1/2 values of Tc-99m DTPA clearance in hyperthyroid group (p > 0.05). Conclusions: We conclude that increased thyroid hormones have no effect on permeability of alveolar-capillary membrane in hyperthyroid patients.en_US
dc.identifier.doi10.1007/BF02985583
dc.identifier.endpage527en_US
dc.identifier.issn0914-7187
dc.identifier.issn1864-6433
dc.identifier.issue6en_US
dc.identifier.pmid16248392en_US
dc.identifier.scopus2-s2.0-27444436562en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage523en_US
dc.identifier.urihttps://doi.org/10.1007/BF02985583
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21712
dc.identifier.volume19en_US
dc.identifier.wosWOS:000232429600015en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofAnnals Of Nuclear Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHyperthyroidismen_US
dc.subjectPulmonary Functionen_US
dc.subjectTc-99m DTPA Aerosol Scintigraphyen_US
dc.subjectAlveolar-Capillary Permeabilityen_US
dc.subjectEpithelial Permeabilityen_US
dc.subjectRat Lungsen_US
dc.subjectTc-99m-Dtpaen_US
dc.subjectThyrotoxicosisen_US
dc.subjectPerformanceen_US
dc.subjectSurfactanten_US
dc.subjectDepositionen_US
dc.titleClearance of technetium-99m-labeled DTPA in hyperthyroidism without clinical evidence of lung disease, and relation to pulmonary functionen_US
dc.typeArticleen_US

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