Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis

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dc.authoridCanberk, Sule/0000-0002-3736-1323
dc.authoridMaximo, Valdemar/0000-0002-8631-8356
dc.authoridCanberk, Sule/0000-0002-3736-1323
dc.authoridSoares, Paula/0000-0001-9607-6998
dc.authoridMaximo, Valdemar/0000-0002-8631-8356
dc.authoridSchmitt, Fernando/0000-0003-1006-6946
dc.authoridBarroca, Helena/0000-0001-5684-3523
dc.authorwosidCanberk, Sule/AAL-5645-2020
dc.authorwosidMaximo, Valdemar/HPD-4236-2023
dc.authorwosidCanberk, Sule/AAM-8781-2020
dc.authorwosidSoares, Paula/B-6054-2008
dc.authorwosidMaximo, Valdemar/E-7480-2011
dc.authorwosidSchmitt, Fernando/A-5270-2008
dc.authorwosidBongiovanni, Massimo/C-3144-2017
dc.contributor.authorCanberk, Sule
dc.contributor.authorBarroca, Helena
dc.contributor.authorGirao, Ines
dc.contributor.authorAydin, Ozlem
dc.contributor.authorUguz, Aysun
dc.contributor.authorErdogan, Kivilcim
dc.contributor.authorTastekin, Ebru
dc.date.accessioned2024-06-12T11:11:57Z
dc.date.available2024-06-12T11:11:57Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: To evaluate the performance of TBSRTC through multi-institutional experience in the paediatric population and questioning the management recommendation of ATA Guidelines Task Force on Paediatric Thyroid Cancer; Methods: A retrospective search was conducted in 4 institutions to identify consecutive thyroid FNAC cases in paediatric population between 2000 and 2018. Following the 2nd TBSRTC, the risk of malignancy ratios (ROMs) was given in ranges and calculated by 2 different ways. Sensitivity, specificity, PPV, NPV and DA ratios were calculated using histologic diagnosis as the gold standard; Results: Among a total of 405 specimens, the distribution of cases for each category was, 44 (11%) for ND, 204 (50%) for B category, 40 (10%) for AUS/FLUS, 36 (9%) for FN/SFN, 24 (6%) for SFM and 57 (14%) for M categories. 153 cases have a histological diagnosis. The ratio of surgery was 23% in ND, 16% in the B, 45% for AUS/FLUS, 75% for SFN/FN and 92% for SFM and 75% in M categories; Conclusions: The data underlines the high ROM values in paediatric population which might be clinically meaningful. The high rate of malignancy of the cohort of operated patients (50%) also underlines the need of better preoperative indicators for stratification. Considering that more than half of the nodules in AUS/FLUS category were benign, direct surgery recommendation could be questionable as proposed in ATA 2015 guidelines.en_US
dc.description.sponsorshipPortuguese funds through FCT-Fundacao para a Ciencia e a Tecnologia [SFRH/BD/147650/2019]; project Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets - Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF) [NORTE-01-0145-FEDER-000051]; Fundação para a Ciência e a Tecnologia [SFRH/BD/147650/2019] Funding Source: FCTen_US
dc.description.sponsorshipThis work was supported by Portuguese funds through FCT-Fundacao para a Ciencia e a Tecnologia-in the framework of a Ph.D. grant to SC (SFRH/BD/147650/2019). This article is partly supported by the project Cancer Research on Therapy Resistance: From Basic Mechanisms to Novel Targets-NORTE-01-0145-FEDER-000051, supported by Norte Portugal Regional Operational Programme (NORTE 2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF).en_US
dc.identifier.doi10.3390/diagnostics12010179
dc.identifier.issn2075-4418
dc.identifier.issue1en_US
dc.identifier.pmid35054346en_US
dc.identifier.scopus2-s2.0-85123066372en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/diagnostics12010179
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22987
dc.identifier.volume12en_US
dc.identifier.wosWOS:000746972000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofDiagnosticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPaediatric Thyroid Nodulesen_US
dc.subjectThe Bethesda System For Reporting Thyroid Cytologyen_US
dc.subjectThyroid Cytologyen_US
dc.subjectTBSRTCen_US
dc.subjectPaediatric Cytologyen_US
dc.subjectFNACen_US
dc.subjectBethesda Systemen_US
dc.subjectFine-Needle-Aspirationen_US
dc.subjectMalignancyen_US
dc.subjectChildrenen_US
dc.subjectRisken_US
dc.subjectManagementen_US
dc.subjectCarcinomaen_US
dc.subjectUtilityen_US
dc.titlePerformance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysisen_US
dc.typeArticleen_US

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