Pimecrolimus 1% cream for pruritus in postmenopausal diabetic women with vulvar lichen simplex chronicus: A prospective non-controlled case series
Küçük Resim Yok
Tarih
2008
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background: Pruritus vulvae may have a variety of causes, such as infections, dermatologic disorders or non-neoplastic/neoplastic vulvar diseases. Objectives: To investigate the efficacy and side effects of topical pimecrolimus 1% cream for pruritus vulvae. Methods: Twelve postmenopausal diabetic women with vulvar lichen simplex chronicus were enrolled in this trial. Each patient was treated with pimecrolimus 1% cream which was applied twice daily in a thin layer to the vulvae for 3 months. Clinical examination and recording of patients' symptoms using a scoring system was performed by the same physician before, after 4 weeks and after 3 months of therapy. Results: All of the patients completed the study. A substantial decrease in pruritus after treatment was reported by the patients at the 4th week (2.17 +/- 0.72, p < 0.01) and 3rd month of treatment (0.42 +/- 0.92, p < 0.001) when compared with the baseline score (3.75 +/- 0.45). Follow-up of the patients after 3 months of treatment showed that complete cure occurred in 10 patients (83.3%) and the pruritus was improved in two (16.7%) patients. Conclusions: Pimecrolimus 1% cream seems to be an effective and safe treatment modality for pruritus in postmenopausal women with vulvar lichen simplex chronicus.
Açıklama
Anahtar Kelimeler
Lichen Simplex Chronicus, Pimecrolimus 1% Cream, Postmenopausal, Vulvar Pruritus, Epidermal Langerhans Cells, Atopic-Dermatitis, Topical Pimecrolimus, Tacrolimus, Corticosteroids, Efficacy, Skin
Kaynak
Journal Of Dermatological Treatment
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
19
Sayı
5
