Effect of epidural levobupivacaine on recovery from vecuronium-induced neuromuscular block in patients undergoing lower abdominal surgery

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dc.authoridŞenol, Mehmet Güney/0000-0001-6397-9293
dc.authoridColak, Alkin/0000-0001-9103-4844
dc.authorwosidŞenol, Mehmet Güney/L-9182-2015
dc.authorwosidSevdi, Mehmet Salih/GZK-4961-2022
dc.authorwosidColak, Alkin/R-8739-2017
dc.contributor.authorSahin, S. H.
dc.contributor.authorColak, A.
dc.contributor.authorSezer, A.
dc.contributor.authorArar, C.
dc.contributor.authorSevdi, S.
dc.contributor.authorGunday, I.
dc.contributor.authorSut, N.
dc.date.accessioned2024-06-12T11:09:06Z
dc.date.available2024-06-12T11:09:06Z
dc.date.issued2011
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe aim of this study was to evaluate the effect of epidural levobupivacaine on recovery from vecuronium-induced neuromuscular block. Ninety patients undergoing lower abdominal surge, were randomised into two groups after an epidural test dose: the epidural group (n=45) received a bolus of 15 nil of 0.5% levobupivacaine whereas the control group (n=45) did not. Anaesthesia was induced and maintained with propofol, fentanyl, vecuronium and nitrous oxide. Neuromuscular block was induced with vecuronium 0.1 mg/kg and monitored with acceleromyographic train-of-four at the adductor pollicis. Patients in each group received neostigmine at 25% recovery of the first twitch of train-of-four during recovery from anaesthesia. The effect of epidural levobupivacaine on the speed of recovery of neuromuscular function was evaluated. The lag time, onset time and time from vecuronium administration until 25% T1 recovery did not differ between the groups. The times of the recovery index (the time from 25% to 75% recovery of T1) and of the DUR 25-train-of-four 90 (time from 25% T1 to train-of-four ratio of 0.9) in the epidural group were significantly longer than those for the control group (5.2 [2.1] vs 3.04 [1.02] minutes and 10.8 [3.3] vs 8.2 [2.3] minutes, P < 0.001). This study shows that epidural levobupivacaine significantly delays the train-of-four recovery from vecuronium-induced block. Although the interaction is small in the clinical setting, anaesthetists should take this interaction into consideration when combining general and epidural anaesthesia during surgery.en_US
dc.identifier.doi10.1177/0310057X1103900411
dc.identifier.endpage610en_US
dc.identifier.issn0310-057X
dc.identifier.issue4en_US
dc.identifier.pmid21823377en_US
dc.identifier.scopus2-s2.0-79960460311en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage607en_US
dc.identifier.urihttps://doi.org/10.1177/0310057X1103900411
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22688
dc.identifier.volume39en_US
dc.identifier.wosWOS:000293264000012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAustralian Soc Anaesthetistsen_US
dc.relation.ispartofAnaesthesia And Intensive Careen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectNeuromuscular Blocken_US
dc.subjectVecuroniumen_US
dc.subjectNeuromuscular Functionen_US
dc.subjectMonitoringen_US
dc.subjectAnaesthetics Localen_US
dc.subjectAnaesthesiaen_US
dc.subjectEpiduralen_US
dc.subjectClinical-Research Practiceen_US
dc.subjectLocal-Anestheticsen_US
dc.subjectMuscle-Relaxantsen_US
dc.subjectProcaineen_US
dc.subjectBupivacaineen_US
dc.subjectJunctionen_US
dc.subjectLignocaineen_US
dc.subjectReceptorsen_US
dc.subjectAgentsen_US
dc.titleEffect of epidural levobupivacaine on recovery from vecuronium-induced neuromuscular block in patients undergoing lower abdominal surgeryen_US
dc.typeArticleen_US

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