Impaired nocturnal synthesis of melatonin in patients with cardiac syndrome X

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dc.authoridAltun, Armagan/0000-0002-3233-8263
dc.authoridvardar, selma arzu/0000-0002-1073-1718
dc.authorwosidAKTOZ, MERYEM/M-9023-2018
dc.authorwosidAltun, Armagan/ABB-5844-2020
dc.contributor.authorAltun, A
dc.contributor.authorYaprak, M
dc.contributor.authorAktoz, M
dc.contributor.authorVardar, A
dc.contributor.authorBetul, U
dc.contributor.authorOzbay, G
dc.date.accessioned2024-06-12T11:09:05Z
dc.date.available2024-06-12T11:09:05Z
dc.date.issued2002
dc.departmentTrakya Üniversitesien_US
dc.description.abstractWe investigated nocturnal secretion pattern of melatonin in patients with cardiac syndrome X and healthy subjects. The present study performed in five patients with cardiac syndrome X and in nine healthy controls. Blood samples from all subjects were collected every 2 h intervals between 22:00 and 08:00 h. Melatonin levels were measured with a radioimmunoassay kit. Patients with cardiac syndrome X secreted less nocturnal melatonin at 02:00 h than control subjects (P = 0.04). Peak and Delta melatonin (peak-lowest melatonin) were found lower in patients with cardiac syndrome X (P = 0.039 and P = 0.028, respectively). In conclusion patients with cardiac syndrome X show a markedly decreased nocturnal melatonin synthesis. Our study provides useful information about melatonin synthesis and release in patients with cardiac syndrome X might help physicians in managing these patients. (C) 2002 Published by Elsevier Science Ireland Ltd.en_US
dc.identifier.doi10.1016/S0304-3940(02)00368-3
dc.identifier.endpage145en_US
dc.identifier.issn0304-3940
dc.identifier.issue2en_US
dc.identifier.pmid12098655en_US
dc.identifier.scopus2-s2.0-0037135288en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://doi.org/10.1016/S0304-3940(02)00368-3
dc.identifier.urihttps://hdl.handle.net/20.500.14551/22680
dc.identifier.volume327en_US
dc.identifier.wosWOS:000177369800017en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Sci Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNervous Systemen_US
dc.subjectSympathovagal Imbalanceen_US
dc.subjectAnginaen_US
dc.subjectNormal Coronary Angiographyen_US
dc.subjectCoronary-Artery Diseaseen_US
dc.subjectHeart-Diseaseen_US
dc.titleImpaired nocturnal synthesis of melatonin in patients with cardiac syndrome Xen_US
dc.typeArticleen_US

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