Late Versus Early Myocardial Remodeling After Acute Myocardial Infarction: A Comparative Review on Mechanistic Insights and Clinical Implications

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dc.authoridPalabıyık, Orkide/0000-0002-3488-3740
dc.authoridTAYLAN, GOKAY/0000-0002-7015-4537
dc.authoridYILMAZ, Mehmet Birhan/0000-0002-8169-8628
dc.authorwosidPalabıyık, Orkide/Q-2792-2019
dc.authorwosidZorkun, Cafer/S-7132-2016
dc.authorwosidTAYLAN, GOKAY/HJZ-4693-2023
dc.authorwosidYILMAZ, Mehmet Birhan/Y-1372-2019
dc.contributor.authorYalta, Kenan
dc.contributor.authorYilmaz, Mehmet Birhan
dc.contributor.authorYalta, Tulin
dc.contributor.authorPalabiyik, Orkide
dc.contributor.authorTaylan, Gokay
dc.contributor.authorZorkun, Cafer
dc.date.accessioned2024-06-12T10:50:35Z
dc.date.available2024-06-12T10:50:35Z
dc.date.issued2020
dc.departmentTrakya Üniversitesien_US
dc.description.abstractIn the setting of acute myocardial infarction (AMI), adverse myocardial remodeling (AMR) has been universally regarded as an early-onset phenomenon generally arising within the first few weeks (usually within days in the infarct zone) following myocardial injury. On the other hand, onset of cardiac morphological changes in this setting may potentially extend far beyond this time frame (usually beyond several months after the index AMI), suggesting a prolonged latent period in certain cases. In clinical practice, this delayed form of post-AMI remodeling, namely late AMR, has emerged as an interesting and underrecognized phenomenon with poorly understood mechanisms. Notably, systemic inflammation and associated growth factors seem to play a pivotal role in this setting. Accordingly, the present article primarily aims to discuss potential mechanisms and clinical implications of late AMR (in a comparative manner with its classical early counterpart) among AMI survivors along with a particular emphasis on potential benefits of certain anti-inflammatory strategies in this setting.en_US
dc.identifier.doi10.1177/1074248419869618
dc.identifier.endpage26en_US
dc.identifier.issn1074-2484
dc.identifier.issn1940-4034
dc.identifier.issue1en_US
dc.identifier.pmid31416353en_US
dc.identifier.scopus2-s2.0-85071475290en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage15en_US
dc.identifier.urihttps://doi.org/10.1177/1074248419869618
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18060
dc.identifier.volume25en_US
dc.identifier.wosWOS:000483178800001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Incen_US
dc.relation.ispartofJournal Of Cardiovascular Pharmacology And Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAcute Myocardial Infarctionen_US
dc.subjectLate Myocardial Remodelingen_US
dc.subjectEarly Myocardial Remodelingen_US
dc.subjectSystemic Inflammationen_US
dc.subjectGrowth Factorsen_US
dc.subjectClinical Implicationsen_US
dc.subjectArginine-Vasopressin Increasesen_US
dc.subjectHeart-Failureen_US
dc.subjectCardiovascular-Diseaseen_US
dc.subjectInflammatory Responseen_US
dc.subjectRheumatoid-Arthritisen_US
dc.subjectMonoclonal-Antibodyen_US
dc.subjectSt2en_US
dc.subjectTherapyen_US
dc.subjectRepairen_US
dc.subjectDysfunctionen_US
dc.titleLate Versus Early Myocardial Remodeling After Acute Myocardial Infarction: A Comparative Review on Mechanistic Insights and Clinical Implicationsen_US
dc.typeReview Articleen_US

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