Glu298Asp polymorphism of the endothelial nitric oxide synthase gene in Turkish patients with ischemic stroke

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dc.authoridGULDIKEN, Baburhan/0000-0002-9006-1880
dc.authoridbudak, metin/0000-0002-5968-2048
dc.authorwosidBudak, metin/Z-3010-2019
dc.contributor.authorGuldiken, Baburhan
dc.contributor.authorSipahi, Tammam
dc.contributor.authorGuldiken, Sibel
dc.contributor.authorUstundag, Sedat
dc.contributor.authorBudak, Metin
dc.contributor.authorTurgut, Nilda
dc.contributor.authorOzkan, Hulya
dc.date.accessioned2024-06-12T11:00:26Z
dc.date.available2024-06-12T11:00:26Z
dc.date.issued2009
dc.departmentTrakya Üniversitesien_US
dc.description.abstractThe low plasma nitric oxide concentrations and reduced vascular reactivity are considered major proatherogenic mechanisms in cardiovascular diseases. The present study aimed to assess the allelic frequency and the genotypic distribution of the Glu298Asp gene polymorphism at exon 7 of endothelial nitric oxide synthase (eNOS) gene in Turkish ischemic stroke patients compared to appropriate healthy controls, and to correlate the genetic findings with stroke subtypes. The study population included 146 (75 males, 71 females) patients with ischemic stroke which were categorized according to the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) and 133 (34 males, 99 females) healthy subjects. The eNOS polymorphism was identified with a PCR followed by RFLP with the restriction enzyme BanII. Genotypes were defined as GG, GT, and TT according to the presence of the G and T alleles. In this case-control study, we did not find any significant difference in either the genotypic distribution or allelic frequency of Glu298Asp gene polymorphism between the patients and the controls. In addition, there was also no significant difference for the genotype distribution and the allelic frequency among the stroke subtypes. The results suggested the lack of the association between the Glu298Asp gene polymorphism and ischemic stroke or subtypes of ischemic stroke in the Turkish population.en_US
dc.identifier.doi10.1007/s11033-008-9348-7
dc.identifier.endpage1543en_US
dc.identifier.issn0301-4851
dc.identifier.issue6en_US
dc.identifier.pmid18781402en_US
dc.identifier.scopus2-s2.0-67651094030en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1539en_US
dc.identifier.urihttps://doi.org/10.1007/s11033-008-9348-7
dc.identifier.urihttps://hdl.handle.net/20.500.14551/20832
dc.identifier.volume36en_US
dc.identifier.wosWOS:000266454500046en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEnosen_US
dc.subjectIschemic Strokeen_US
dc.subjectGene Polymorphismen_US
dc.subjectGlu298Aspen_US
dc.subjectBlood-Flowen_US
dc.subjectRisken_US
dc.subjectDiseaseen_US
dc.subjectAssociationen_US
dc.subjectPopulationen_US
dc.subjectHaplotypesen_US
dc.subjectInfarctionen_US
dc.titleGlu298Asp polymorphism of the endothelial nitric oxide synthase gene in Turkish patients with ischemic strokeen_US
dc.typeArticleen_US

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