Assessment of digital ischaemia and evaluation of response to therapy by 99mTc sestamibi limb scintigraphy after local cooling of the hands in patients with vasospastic Raynaud's syndrome

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dc.contributor.authorSarikaya, A
dc.contributor.authorEge, T
dc.contributor.authorFirat, MF
dc.contributor.authorDuran, E
dc.date.accessioned2024-06-12T11:17:02Z
dc.date.available2024-06-12T11:17:02Z
dc.date.issued2004
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAim Cold induced arteriolar constriction in patients with vasospastic Raynaud's syndrome (VRS) produces temporary digital ischaemia. The aim of this study was to ascertain whether Tc-99m sestamibi scintigraphy is useful in the diagnosis and the monitoring of treatment in VRS. Methods Fifteen patients with VRS and 20 matched normal controls underwent examination. Twelve patients with VRS received therapy. For each patient one hand was immersed in iced water for 30s while the other hand served as a control. Ten minutes after cooling, Tc-99m sestamibi was injected and imaging was performed 60 min later. The per cent decrease of the perfusion (%DP) was calculated by semiquantitative analysis to determine the severity of hypoperfusion. Results In all patients with VRS, moderate or marked hypoperfusion were seen in (TC)-T-99m sestamibi images after exposure to the iced water, while there was minimal or mild hypoperfusion in the control groups. Values for %DP were 46.86 +/- 19.04 and 7.85 +/- 4.53 for the VRS group and normal subjects, respectively. The difference between both groups was statistically significant (P = 0.0000). In 12 treated patients with VRS, pre-treatment and post-treatment %DP values were 51.16 +/- 18.42 and 33.58 +/- 17.83, respectively, and a significant difference was seen between both values (P = 0.001). However, there was still a statistically significant difference between control subjects and post-therapy values (7.85 +/- 4.53 vs. 33.58 +/- 17.83, P = 0.0000). The +/- 95% confidence interval of DIP for control subjects was 5.7-10% (chi-squared, P = 0.000). When a DIP of 10% was used as a cut-off point, sensitivity, specificity and diagnostic accuracy were 100%, 70% and 83%, respectively, for the Tc-99m sestamibi scan. There was also a strong correlation between %DP and the duration of the disease (r = 0.80, P = 0.0003). Conclusion The results of this study indicate that a Tc-99m sestamibi scan is a valuable imaging method for the determination of digital ischaemia in vasospastic Raynaud's syndrome, and may play a role in evaluating the response to therapy. (C) 2004 Lippincott Williams Wilkins.en_US
dc.identifier.doi10.1097/01.mnm.0000109832.10116.f3
dc.identifier.endpage211en_US
dc.identifier.issn0143-3636
dc.identifier.issn1473-5628
dc.identifier.issue2en_US
dc.identifier.pmid15154713en_US
dc.identifier.startpage207en_US
dc.identifier.urihttps://doi.org/10.1097/01.mnm.0000109832.10116.f3
dc.identifier.urihttps://hdl.handle.net/20.500.14551/24556
dc.identifier.volume25en_US
dc.identifier.wosWOS:000220962600019en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofNuclear Medicine Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVasospastic Raynaud's Syndromeen_US
dc.subjectTc-99m Sestamibien_US
dc.subjectScintigraphyen_US
dc.subjectReflex Sympathetic Dystrophyen_US
dc.subjectTechnetium-99m-Sestamibi Scintigraphyen_US
dc.subjectSystemic-Sclerosisen_US
dc.subjectFrostbite Injuryen_US
dc.subjectObjective Testen_US
dc.subjectMuscleen_US
dc.subjectDiagnosisen_US
dc.subjectViabilityen_US
dc.subjectFlowen_US
dc.titleAssessment of digital ischaemia and evaluation of response to therapy by 99mTc sestamibi limb scintigraphy after local cooling of the hands in patients with vasospastic Raynaud's syndromeen_US
dc.typeArticleen_US

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