Increased platelet activation markers in rheumatoid arthritis

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dc.authorwosidCakir, Necati/AAG-7283-2019
dc.authorwosidTurgut, Burhan/A-2517-2016
dc.contributor.authorPamuk, Guelsuem Emel
dc.contributor.authorVural, Oezden
dc.contributor.authorTurgut, Burhan
dc.contributor.authorDemir, Muzaffer
dc.contributor.authorPamuk, Oemer Nuri
dc.contributor.authorCakir, Necati
dc.date.accessioned2024-06-12T11:13:39Z
dc.date.available2024-06-12T11:13:39Z
dc.date.issued2008
dc.departmentTrakya Üniversitesien_US
dc.description.abstractAtherosclerotic cardiovascular mortality is increased in rheumatoid arthritis (RA) patients. We evaluated the association of inflammatory response with platelet, endothelial, coagulation activation parameters; and subclinical atherosclerosis in RA patients. We included 27 RA patients (21 female; six male) and 19 healthy subjects (14 female; five male). Disease activity score (DAS28) in RA patients was calculated; and patients were divided into two groups as active and inactive. Flow cytometry was used to determine platelet CD62P expression, platelet microparticles (PMP), platelet-monocyte (PMC) and platelet-neutrophil complexes (PNC). Plasma E-selectin, thrombin-antithrombin (TAT) complex, and serum sCD40L levels were determined by ELISA. The intima-media thickness (IMT) of carotid arteries was determined by B-mode ultrasonography. In RA patients, platelet CD62P expression (p< 0.001), PMC (p = 0.037) and sCD40L (p< 0.001) levels were increased when compared to the control group. PNC (p = 0.07) and TAT levels (p = 0.1) were non-significantly higher, and PMP level (p = 0.075) was nonsignificantly lower in RA patients. Soluble E-selectin level was significantly higher in the active RA group than in the inactive RA group (p = 0.009). There was no correlation between carotid IMT and activity markers, the evaluated parameters (p>0.05).The increase in markers of active platelets, CD62P and sCD40L, and PMC levels might be associated with the increased cardiovascular mortality in RA. Nevertheless, none of these parameters were associated with carotid IMT: this suggests that one cross-sectional value might not be a good marker for atherosclerosis.en_US
dc.identifier.doi10.1080/09537100701210057
dc.identifier.endpage154en_US
dc.identifier.issn0953-7104
dc.identifier.issn1369-1635
dc.identifier.issue2en_US
dc.identifier.pmid17852775en_US
dc.identifier.scopus2-s2.0-39749193487en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage146en_US
dc.identifier.urihttps://doi.org/10.1080/09537100701210057
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23637
dc.identifier.volume19en_US
dc.identifier.wosWOS:000253513900009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofPlateletsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectRheumatoid Arthritisen_US
dc.subjectCD40 Liganden_US
dc.subjectInflammationen_US
dc.subjectCD62Pen_US
dc.subjectPlatelet-Monocyte Complexen_US
dc.subjectPlatelet-Neutrophil Complexen_US
dc.subjectP-Selectinen_US
dc.subjectDisease-Activityen_US
dc.subjectIncreased Prevalenceen_US
dc.subjectCd40 Liganden_US
dc.subjectSe-Selectinen_US
dc.subjectMicroparticlesen_US
dc.subjectInflammationen_US
dc.subjectExpressionen_US
dc.subjectClassificationen_US
dc.subjectMonocytesen_US
dc.titleIncreased platelet activation markers in rheumatoid arthritisen_US
dc.typeArticleen_US

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