A comparative histopathological and immunohistochemical study of Survivin and Ki-67 proteins in glial tumours

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dc.authoridbudak, metin/0000-0002-5968-2048
dc.authorwosidBudak, metin/Z-3010-2019
dc.authorwosidYILDIZ, Mustafa/B-7520-2016
dc.authorwosidYILDIZ, Mustafa/P-9934-2015
dc.contributor.authorTopyalin, Nur
dc.contributor.authorBudak, Metin
dc.contributor.authorOzbay, Nurver
dc.contributor.authorYildiz, Mustafa
dc.contributor.authorKaner, Tuncay
dc.contributor.authorAydin, Abdullah
dc.contributor.authorGezen, Ahmet Ferruh
dc.date.accessioned2024-06-12T11:02:40Z
dc.date.available2024-06-12T11:02:40Z
dc.date.issued2019
dc.departmentTrakya Üniversitesien_US
dc.description.abstractSurvivin is a bifunctional protein which regulates cell division and inhibits apoptosis. Survivin is a member of the inhibitor of apoptosis protein (IAP) family. Expression of survivin has been shown to be responsible for apoptosis and resistance to ionizing radiation. The aim of the present study was to investigate the association between -31 G/C promoter polymorphism, survivin protein and glial tumour grading, and to compare survivin versus Ki-67 as a marker. In this study, DNA was isolated from paraffin-embedded sections of 29 patients diagnosed with glial tumours. Survivin gene promoter -31 G/C polymorphism was investigated using PCR-RFLP. For the analysis, 10 mu m sections were stained with survivin protein and Ki-67 antibody. Immunohistochemical staining was performed. Survivin showed a positive correlation with Ki-67 (r = 0.604; p = 0.001). The tumour grades correlated with survivin; however, the relationship was not statistically significant (r = 0.345; p > 0.05). We found a significant correlation between tumour grades and Ki-67 (r = 0.663; p < 0.01), suggesting that Ki-67 is a more sensitive marker compared to survivin.en_US
dc.description.sponsorshipScientific Research Projects Management Unit of Istanbul Medeniyet University - Turkey [T-Uzm-2016-858]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Management Unit of Istanbul Medeniyet University - Turkey - under Project Grant number T-Uzm-2016-858.en_US
dc.identifier.doi10.1080/13102818.2019.1591931
dc.identifier.endpage509en_US
dc.identifier.issn1310-2818
dc.identifier.issn1314-3530
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85063736572en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage504en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2019.1591931
dc.identifier.urihttps://hdl.handle.net/20.500.14551/21377
dc.identifier.volume33en_US
dc.identifier.wosWOS:000465759100001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnology & Biotechnological Equipmenten_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGlial Tumouren_US
dc.subjectSurvivinen_US
dc.subjectPolymorphismen_US
dc.subjectKi-67en_US
dc.subjectPromoter Polymorphismen_US
dc.subjectNuclear Survivinen_US
dc.subjectExpressionen_US
dc.subjectGliomaen_US
dc.subjectGeneen_US
dc.subjectResistanceen_US
dc.subjectApoptosisen_US
dc.subjectCellsen_US
dc.subjectRisken_US
dc.titleA comparative histopathological and immunohistochemical study of Survivin and Ki-67 proteins in glial tumoursen_US
dc.typeArticleen_US

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