A novel biomarker in acute cholecystitis: YKL-40

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dc.authoridcelikturk, eray/0000-0002-1183-6511
dc.authoridSALT, OMER/0000-0002-5557-6627
dc.authorwosidcelikturk, eray/HNJ-4294-2023
dc.contributor.authorCelikturk, Eray
dc.contributor.authorSalt, Omer
dc.contributor.authorSayhan, Mustafa Burak
dc.contributor.authorDibirdik, Ilker
dc.date.accessioned2024-06-12T10:50:32Z
dc.date.available2024-06-12T10:50:32Z
dc.date.issued2023
dc.departmentTrakya Üniversitesien_US
dc.description.abstractBackground: The lack of a specific biomarker that can be used in the diagnosis of acute cholecystitis, a common cause of admission to the emergency department, delays physician efforts to diagnose and treat these patients. Therefore, the aim of this study was to measure plasma YKL-40 levels and investigate their diagnostic value in patients with acute cholecystitis (AC). Methods: This study was carried out between February 2020 and September 2020 in the adult emergency department of a tertiary university hospital. Permission was obtained from the Ethics Committee of Scientific Research on 03/02/2020 with Decision No. 03/16. The study included 80 patients who were diagnosed with acute cholecystitis and 80 healthy volunteers without known chronic diseases. Results: The median YKL-40 protein level was 798.66 pq/mL in the patient group and 392.45 pq/mL in the control group. A statistically significant difference in YKL-40 protein levels was found between the two groups. YKL-40 protein levels were significantly higher in patients diagnosed with acute cholecystitis than in healthy individuals (p < 0.001). A positive correlation was found between YKL-40 protein levels and ALT, AST, LDH, and GGT levels (r = 0.272, p = 0.015; r = 0.397, p < 0.001; r = 0.386, p < 0.001; and r = 0.264, p = 0.018; respectively). Conclusion: When evaluated together with physical examination, radiological imaging and other laboratory parameters, we think that plasma YKL-40 levels can be used effectively in the diagnosis of acute cholecystitis. (c) 2023 Asian Surgical Association and Taiwan Robotic Surgery Association. Publishing services by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/ by/4.0/).en_US
dc.identifier.doi10.1016/j.asjsur.2022.09.073
dc.identifier.endpage1570en_US
dc.identifier.issn1015-9584
dc.identifier.issn0219-3108
dc.identifier.issue4en_US
dc.identifier.pmid36241524en_US
dc.identifier.scopus2-s2.0-85139729924en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1564en_US
dc.identifier.urihttps://doi.org/10.1016/j.asjsur.2022.09.073
dc.identifier.urihttps://hdl.handle.net/20.500.14551/18038
dc.identifier.volume46en_US
dc.identifier.wosWOS:000999267700001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Singapore Pte Ltden_US
dc.relation.ispartofAsian Journal Of Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Cholecystitisen_US
dc.subjectEmergency Medicineen_US
dc.subjectYKL-40en_US
dc.subjectPlasma Ykl-40en_US
dc.subjectSerum Ykl-40en_US
dc.subjectAcute Cholangitisen_US
dc.subjectInflammationen_US
dc.subjectProteinsen_US
dc.subjectChi3l1en_US
dc.subjectSeverityen_US
dc.subjectMarkeren_US
dc.subjectIdentificationen_US
dc.subjectProcalcitoninen_US
dc.titleA novel biomarker in acute cholecystitis: YKL-40en_US
dc.typeArticleen_US

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