Assessing the Correlation Between 68Ga-PSMA-11 Renal PET Parameters and Renal Function Tests

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dc.authoridSarikaya, Ismet/0000-0002-1087-580X
dc.authoridSchierz, Jan-Henning/0000-0002-6517-6029
dc.authoridAlbatineh, Ahmed Najeeb/0000-0001-5646-4945
dc.authorwosidSarikaya, Ismet/G-7881-2015
dc.authorwosidSchierz, Jan-Henning/AAC-1692-2022
dc.contributor.authorSchierz, Jan-Henning
dc.contributor.authorSarikaya, Ismet
dc.contributor.authorAlbatineh, Ahmed N.
dc.contributor.authorSarikaya, Ali
dc.date.accessioned2024-06-12T11:12:19Z
dc.date.available2024-06-12T11:12:19Z
dc.date.issued2022
dc.departmentTrakya Üniversitesien_US
dc.description.abstractGa-68-prostate-specific membrane antigen (PSMA) ligands are used for prostate cancer but also show high renal cortical uptake. In this study, we aimed to assess whether there is any correlation between renal PSMA PET parameters and renal function tests using the images of prostate cancer patients. Methods: (68)GaPSMA-11 PET/CT images of the patients with prostate cancer were retrospectively evaluated. The following PET parameters were obtained: SUVmax, SUVmean, SUVmax corrected for lean body weight, SUVmean corrected for lean body weight, volume, lean body weight-corrected total lesion glycolysis (TLG(SUL)), and counts of both kidneys, as well as SUVmean of the liver, blood pool, and spleen. Total TLG(SUL), total volume, kidney-to-liver ratio, and kidney-to-blood pool ratio were calculated. Creatinine values were obtained, and glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease formula. Statistical analysis was performed to understand whether there is a correlation between the above parameters and renal function tests. Results: Twenty-five patients were included in this study. GFR was significantly and positively correlated and creatinine was significantly and negatively correlated with the ratios of renal SUV to liver SUV and renal SUV to blood pool SUV. GFR was marginally positively correlated with renal SUVmean corrected for lean body weight, and creatinine was marginally negatively correlated with total TLG(SUL). Total renal parenchymal volume was significantly and directly (positively) associated with GFR and significantly and inversely (negatively) associated with creatinine. Conclusion: Renal Ga-68-PSMA uptake appears to be correlated with renal function tests. Our method of measuring approximate renal parenchymal volume on PET images appears to be reliable.en_US
dc.identifier.doi10.2967/jnmt.121.262462
dc.identifier.endpage48en_US
dc.identifier.issn0091-4916
dc.identifier.issn1535-5675
dc.identifier.issue1en_US
dc.identifier.pmid34330809en_US
dc.identifier.scopus2-s2.0-85118275589en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage43en_US
dc.identifier.urihttps://doi.org/10.2967/jnmt.121.262462
dc.identifier.urihttps://hdl.handle.net/20.500.14551/23120
dc.identifier.volume50en_US
dc.identifier.wosWOS:000994958100004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSoc Nuclear Medicine Incen_US
dc.relation.ispartofJournal Of Nuclear Medicine Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPET/CTen_US
dc.subjectGa-68 PSMA-11en_US
dc.subjectKidneyen_US
dc.subjectRenal Functionen_US
dc.subjectGlomerular-Filtration-Rateen_US
dc.subjectMembrane Antigenen_US
dc.subjectProstateen_US
dc.subjectExpressionen_US
dc.subjectScintigraphyen_US
dc.subjectSpecificityen_US
dc.subjectImpacten_US
dc.subjectLiganden_US
dc.subjectDmsaen_US
dc.subjectMrien_US
dc.titleAssessing the Correlation Between 68Ga-PSMA-11 Renal PET Parameters and Renal Function Testsen_US
dc.typeArticleen_US

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